PDF
ePub
Citation
Print
Abstract
There have been several reported cases of acute lymphoblastic leukemia with severe lactic acidosis in adults. In these cases, kidney and liver enlargement that was caused by leukemic infiltration frequently accompanied the acute lymphoblastic leukemia and severe lactic acidosis. Chemotherapy is the only treatment that can rapidly correct the lactic acidosis and normalize the liver and kidney enlargement. We report here on a case of acute lymphoblastic leukemia that was accompanied with severe lactic acidosis and kidney enlargement.
REFERENCES
1). Friedenberg AS., Brandoff DE., Schiffman FJ. Type B lactic acidosis as a severe metabolic complication in lymphoma and leukemia: a case series from a single institution and literature review. Medicine (Baltimore). 2007. 86:225–32.
2). Sillos EM., Shenep JL., Burghen GA., Pui CH., Behm FG., Sandlund JT. Lactic acidosis: a metabolic complication of hematologic malignancies: case report and review of the literature. Cancer. 2001. 92:2237–46.
3). De Keulenaer B., Van Outryve S., De Backer A, et al. Symptomatic lactic acidosis due to relapse of T-cell acute lymphoblastic leukaemia in the kidney. Nephrol Dial Transplant. 2003. 18:1214–6.
4). Hayek M., Srinivasan A. Acute lymphoblastic leukemia presenting with lactic acidosis and renal tubular dysfunction. J Pediatr Hematol Oncol. 2003. 25:488–90.
5). Svahn J., Schiaffino MC., Caruso U., Calvillo M., Minniti G., Dufour C. Severe lactic acidosis due to thiamine deficiency in a patient with B-cell leuke-mia/lymphoma on total parenteral nutrition during high-dose methotrexate therapy. J Pediatr Hematol Oncol. 2003. 25:965–8.
6). Makino H., Noda K., Inagaki Y, et al. Lactic acidosis and hypoglycemia associated with acute leukemia. Jap J Med. 1985. 24:257–62.
7). Ali AA., Flombaum CD., Brochstein JA., Gillio AP., Bussel JB., Boulad F. Lactic acidosis and renal enlargement at diagnosis and relapse of acute lymphoblastic leukemia. J Pediatr. 1994. 125:584–6.
XML Download