Reverse Seroconversion of Hepatitis B following Allogenic Hematopoietic Stem Cell Transplantation from a Hepatitis Immune Donor in a Multiple Myeloma Patient

Bo Ran Kwon; Jung Ha Mok; Jung Ho Bae; Hee Yun Seol; Young Mi Seol; Moo-Kon Song; Young Jin Choi; Ho Jin Shin; Joo Seop Chung; Goon Jae Cho

doi:10.5045/kjh.2008.43.2.122

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Kwon, Mok, Bae, Seol, Seol, Song, Choi, Shin, Chung, and Cho: Reverse Seroconversion of Hepatitis B following Allogenic Hematopoietic Stem Cell Transplantation from a Hepatitis Immune Donor in a Multiple Myeloma Patient

Case Report

Korean J Hematol 2008;43(2):122-125.

Published online: 19 June 2008

DOI: https://doi.org/10.5045/kjh.2008.43.2.122

Reverse Seroconversion of Hepatitis B following Allogenic Hematopoietic Stem Cell Transplantation from a Hepatitis Immune Donor in a Multiple Myeloma Patient

Bo Ran Kwon, M.D., Jung Ha Mok, M.D., Jung Ho Bae, M.D., Hee Yun Seol, Young Mi Seol, M.D., Moo-Kon Song, M.D., Young Jin Choi, M.D., Ho Jin Shin, M.D., Joo Seop Chung, M.D., Goon Jae Cho, M.D.

Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea

Correspondence to：Joo Seop Chung, M.D. Department of Internal Medicine, Pusan National University Hospital 10, Amidong 1-ga, Seo-gu, Busan 602-739, Korea Tel: ＋82-51-240-7224, Fax: ＋82-51-254-3127 E-mail: hemon@pusan.ac.kr

Received 3 April 2008 Revised 19 June 2008 Accepted 23 June 2008

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A 52-yr-old male with multiple myeloma underwent autologous stem cell transplantation in June 2002. In August 2004, the multiple myeloma had recurred. The patient received allogenic stem cell transplantation in September 2005. Before undergoing transplantation, the presence of HBsAb and the absence of HBsAg were noted. The patient underwent allogenic peripheral blood stem cell transplantation (PBSCT) from a sibling donor who was hepatitis surface antibody (HBsAb) positive and hepatitis surface antigen (HBsAg) negative. Nineteen months after the PBSCT, the liver function tests showed elevation of the aminotransferases. The patient was HBsAg positive and HBsAb negative. The liver biopsy specimen revealed hepatitis. The reactivation of a hepatitis B virus infection, in a hepatitisB immune patient, referred to as reverse seroconversion, is a rare complication of hematopoietic stem cell transplantation.

Keywords: Hepatitis B virus, Seroconversion, Multiple myeloma, Stem cell transplantation

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Fig. 1

Liver biopsy (H&E stain, x200).

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