Small Intestinal Mucosa Associated Lymphoid Tissue (MALT) Lymphoma in a Child Presenting with Recurrent Intussusception: A Case Report

Hye-Eun Seo; Ji Hye Lee; Tae In Park; Kun Soo Lee

doi:10.5045/kjh.2007.42.4.419

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Seo, Lee, Park, and Lee: Small Intestinal Mucosa Associated Lymphoid Tissue (MALT) Lymphoma in a Child Presenting with Recurrent Intussusception: A Case Report

Case Report

Korean J Hematol 2007;42(4):419-422.

Published online: 19 January 2007

DOI: https://doi.org/10.5045/kjh.2007.42.4.419

Small Intestinal Mucosa Associated Lymphoid Tissue (MALT) Lymphoma in a Child Presenting with Recurrent Intussusception: A Case Report

Hye-Eun Seo, M.D., Ji Hye Lee, M.D., Tae In Park, M.D.¹, Kun Soo Lee, M.D.

Department of Pediatrics and Pathology, Daegu, Korea

¹Department of Pediatrics and Pathology, Kyungpook National University School of Medicine, Daegu, Korea

Correspondence to：Kun Soo Lee, M.D. Department of Pediatrics, Kyungpook National University Hospital 50, Samduck-dong 2-ga, Jung-gu, Daegu 700-721, Korea Tel: ＋82-53-420-5713, Fax: ＋82-53-425-6683 E-mail: kslee@knu.ac.kr

Received 1 October 2007 Revised 20 November 2007 Accepted 26 November 2007

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mucosa associated lymphoid tissue (MALT) lymphoma is a malignant B cell lymphoma that develops from MALT. The stomach is the most common site of MALT lymphomas but be found anywhere in the body. Adult MALT lymphomas are not rare diseases, but in children, intestinal MALT lymphomas are very rare. We treated a 12-year-old boy who underwent segmental resection of the small intestine due to recurrent intussusceptions, 2 months apart, and was diagnosed with an intestinal MALT lymphoma. He received multiple chemotherapeutic agents (vincristin, cyclophosphamide, prednisone, methotrexate, doxorubicin and cytosine arabinoside) according to the CCG-5961 protocol for 3 months. Currently, he is alive and disease free.

Keywords: Intestinal mucosa associated lymphoid tissue lymphoma, Recurrent intussusception, Chemotherapy

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Fig. 1

Contrast enhanced CT scan demonstrates ileo-ileal type of intussusception (A) and polyp (B) in the right lower abdominal cavity.

Fig. 2

Microscopic finding of intestinal MALT lymphoma. (A) Reactive lymphoid follicles and intermediate lymphocytes in lamina propria and submucosal area (H&E stain, ×100). (B) Diffuse infiltration of small to medium sized atypical lymphoid cells with irregular nuclear membrane and clump chromatin pattern and plasma cell infiltration (H&E stain, ×400).

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