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Abstract
Many chemotherapeutic agents induce variable cutaneous adverse reactions. Among the side effects, Stevens-Johnson syndrome is rare, but a fatal complication. There are two prior reports of cytosine arabinoside (ARA-C) induced toxic epidermal necrolysis, which is considered in the continuum of Stevens-Johnson syndrome. The prior cases were female patients under 16 years old with acute lymphocytic leukemia. We treated a 77-year-old man with recurrent mantle cell lymphoma who developed Stevens-Johnson syndrome after high dose ARA-C therapy. This is the first case of ARA-C induced Stevens-Johnson syndrome in Korea.
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Fig. 1
Erythematous skin lesion with multiple petechia was showen in the patient's back. Single vesicle was also noted.
Fig. 2
(A) The epidermis of skin biopsy shows subepidermal blister formation with scattered apoptotic keratinocytes (H&E ×100). (B) The dermis of skin biopsy shows mild perivascular lymphohistocytic infiltration with mild erythrocyte extravasation (H&E, ×200).
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