Journal List > Korean J Hematol > v.42(3) > 1032722

Lee: Cord Blood - Current Status and Perspective

Abstract

Umbilical cord blood (CB) is increasingly used as a source of stem cells to repopulate bone marrow in the treatment of life-threatening diseases in children and adults. I review the relationship between the placenta and circulating CB stem cells for hematopoiesis, the clinical results of cord blood stem cell transplantation, and I particularly emphasizethe criteria of CB donor choice. The scientific progress for the use of CB has resulted in the organization of CB banks all over the world. I also review the status of CB banks and networking systems worldwide as recipients of government-based political support.

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Fig. 1
Feto-placental circulation (from Biology in Cornell University, Fall 2007).
kjh-42-181f1.tif
Fig. 2
Cytokine production from placenta and interaction with hematopoietic stem cells in fetal circulation.
kjh-42-181f2.tif
Fig. 3
Number of cord blood stem cell transplantation in Korea.
kjh-42-181f3.tif
Fig. 4
The structure of organization of FACT.
kjh-42-181f4.tif
Table 1.
NetCORD inventory and use on June, 2007
CB bank Inventory Transplanted Children Adults
Athens 450 5 4 1
AusCord 17,547 293 168 105
Barcelona 7,328 331 160 167
Dusseldorf 11,957 416 219 183
France Cord 5,927 565 214 351
Gauting 2,029 27 14 13
Helsinki 2,723 14 8 6
Houston 2,581 20 14 6
Jerusalem 723 12 12 0
Leiden 3,389 54 24 30
Leuven 7,811 99 58 41
Leige 5,013 179 72 107
London 8,406 168 100 68
Malaga 6,800 54 16 38
Mannhelm 1,628 25 15 10
Mexico-CNTS 942 50 29 21
Milan (Grace) 12,344 480 264 216
New York 33,242 2,371 1,540 831
Prague 2,677 14 8 6
Santiago de Compostela 4,792 33 20 13
Seoul 4,135 8 0 8
Tel Hashmer 1,320 4 4 1
Tokyo 4,915 665 193 472
Total 148,679 5,887 3,156 2,694
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