Azacitidine-induced Hepatotoxicity in a Patient with Myelodysplastic Syndrome

Jin-Soo Kim; Joo-Han Lim; Hyeon-Gyu Yi; Hyunmin Park; Moon Hee Lee; Chul Soo Kim

doi:10.5045/kjh.2007.42.2.76

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Kim, Lim, Yi, Park, Lee, and Kim: Azacitidine-induced Hepatotoxicity in a Patient with Myelodysplastic Syndrome

Case Report

Korean J Hematol 2007;42(2):176-179.

Published online: 19 June 2007

DOI: https://doi.org/10.5045/kjh.2007.42.2.76

Azacitidine-induced Hepatotoxicity in a Patient with Myelodysplastic Syndrome

Jin-Soo Kim, M.D., Joo-Han Lim, M.D.¹, Hyeon-Gyu Yi, M.D.¹, Hyunmin Park, M.D., Moon Hee Lee, M.D., Chul Soo Kim, M.D.

Division of Hematology/Oncology, Departments of Medicine, Inha University Hospital, Incheon, Korea

¹Seoul National University Hospital, Seoul, Korea

Correspondence to：Chul Soo Kim, M.D. Department of Medicine, Inha University Hospital 7-206, Shinheung-dong, Jung-gu, Incheon 400-711, Korea Tel: ＋82-32-890-2581, Fax: ＋82-32-890-2585 E-mail: cskimmd@inha.ac.kr

Received 30 April 2007 Revised 8 June 2007 Accepted 13 June 2007

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hematopoietic stem cell transplantation remains the only curative option for myelodysplastic syndrome (MDS), but the prevalence of the disease in elderly people limits broad application of the procedure, particularly in lower risk group. Azacitidine has been recently approved by the U.S. Food and Drug Administration for MDS regardless of subtype on French-American-British classification. Adverse effects of azacitidine include gastrointestinal, hematological and infusion-related reactions. Azacitidine induced hepatotoxicity has been reported mainly in patients with previous hepatobiliary disease, e.g., extensive tumor infiltration in liver, liver cirrhosis and cholelithiasis. We report here a case of azacitidine-induced hepatitis under no predisposition to hepatobiliary disease.

Keywords: Myelodysplastic syndrome, Azacitidine, Adverse effects, Hepatitis, Toxic, Hepatitis, Drug-induced

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Fig. 1

Laboratory trends during follow-up period.

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