A Case of Mantle Cell Lymphoma Treated with Autologous Stem Cell Transplantation and Rituximab

So Yeon Oh; Moon Ju Jang; Sei Kyung Chang; Doyeon Oh; So Young Chong

doi:10.5045/kjh.2006.41.3.215

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Oh, Jang, Chang, Oh, and Chong: A Case of Mantle Cell Lymphoma Treated with Autologous Stem Cell Transplantation and Rituximab

Case Report

Korean J Hematol 2006;41(3):215-219.

Published online: 19 September 2006

DOI: https://doi.org/10.5045/kjh.2006.41.3.215

A Case of Mantle Cell Lymphoma Treated with Autologous Stem Cell Transplantation and Rituximab

So Yeon Oh, M.D.¹, Moon Ju Jang, M.D.¹, Sei Kyung Chang, M.D.², Doyeon Oh, M.D.¹, So Young Chong, M.D.^1,

¹Department of Internal Medicine, Korea

²Department of Radiation Oncology, Pochon CHA University College of Medicine, Seongnam, Korea

Correspondence to : So Young Chong, M.D. Department of Internal Medicine, Pochon CHA University College of Medicine 351, Yatap-dong, Bundang-gu, Seongnam 463-712, Korea Tel: +82-31-780-5154, Fax: +82-31-780-5219 E-mail: sychong@cha.ac.kr

Received 31 October 2005 Revised 7 June 2005 Accepted 9 June 2005

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mantle cell lymphoma is a subtype of aggressive non-Hodgkin's lymphoma and usually presents in advanced stages. When treated with a regimen such as CHOP, the median survival is about three years. More aggressive front-line therapy with the hyper-CVAD regimen or high-dose therapy with stem cell support has shown encouraging results in several trials. The addition of rituximab to the chemotherapy regimens, or high-dose therapy, increased the response and survival rates in patients with mantle cell lymphoma. We report a case of mantle cell lymphoma that was successfully treated with aggressive front-line treatment strategies. The patient achieved complete remission with initial hyper-CVAD regimen, and was consolidated with autologous stem cell transplantation and subsequent rituximab.

Keywords: Mantle cell lymphoma, Hyper-CVAD, Rituximab, Autologous stem cell transplantation

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Fig. 1

Abdomen-pelvic CT shows massive splenomegaly.

Fig. 2

Positron emission tomography shows marked splenomegaly and diffusely increased uptake of FDG at spleen.

Fig. 3

Bone marrow biopsy (H&E stain, ×400). Bone marrow is packed with uniform, small to medium sized lymphoid cells with irregular margin.

Fig. 4

Tumor cells are CD20(+), CD5(+) and cyclin D1(+).

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