Evans Syndrome following T Cell-repleted Unrelated Bone Marrow Transplantation for Myelodysplastic Syndrome: Successful Response to High-dose Corticosteroid

Young-Ho Lee; Young-Dae Kim; Yeong-Myung Kim

doi:10.5045/kjh.2006.41.3.204

Journal List > Korean J Hematol > v.41(3) > 1032676

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Lee, Kim, and Kim: Evans Syndrome following T Cell-repleted Unrelated Bone Marrow Transplantation for Myelodysplastic Syndrome: Successful Response to High-dose Corticosteroid

Case Report

Korean J Hematol 2006;41(3):204-207.

Published online: 19 September 2006

DOI: https://doi.org/10.5045/kjh.2006.41.3.204

Evans Syndrome following T Cell-repleted Unrelated Bone Marrow Transplantation for Myelodysplastic Syndrome: Successful Response to High-dose Corticosteroid

Young-Ho Lee, M.D.^1,, Young-Dae Kim, M.D.², Yeong-Myung Kim, M.D.³

¹Department of Pediatrics Hanyang University Medical Center, Seoul

²Inje University Paik Hospital, Seoul

³Dong-A University Medical Center, Busan, Korea

Correspondence to: Young-Ho Lee, M.D. Department of Pediatrics, Hanyang University Medical Center 17, Haengdang-dong, Seongdong-gu, Seoul 133-792, Korea Tel: +82-2-2290-8383, Fax: +82-2-2297-2380 E-mail: cord@hanyang.ac.kr

Received 2 June 2006 Revised 19 July 2006 Accepted 24 July 2006

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Evans syndrome after hematopoietic stem cell transplantation rarely occurs and this condition is refractory to treatment, particularly in childhood. We experienced a case of Evans syndrome following unmanipulated unrelated bone marrow transplantation. Evans syndrome developed at early post-transplantation period (day +42) and it responded very well to high-dose corticosteroid. Autoimmune cytopenia should be considered for post-engraftment cytopenias and high-dose corticosteroid therapy might be considered as a treatment of the early onset type of autoimmune cytopenia that can occur after hematopoietic stem cell transplantation.

Keywords: Evans syndrome, T cell repleted bone marrow transplantation, High-dose corticosteroid

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Fig. 1

Laboratory parameters before and after onset of Evans syndrome following unrelated bone marrow transplantation. Abbreviations: PLT, platelet; Hb, hemoglobin.

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