Journal List > Korean J Hematol > v.41(2) > 1032665

Kwon, Joeng, Kim, Kim, Lee, Youn, Lee, Lee, Kwon, and Park: Two Cases of Cytomegalovirus Pneumonia after CD34 Selected Autologous Stem Cell Transplantation

Abstract

Cytomegalovirus (CMV) pneumonia is an important cause of treatment related mortality after allogeneic stem cell transplantation (SCT) and autologous SCT, particularly in a CD34 selected setting. There is little known about the immune reconstitution pertaining to the CMV after CD34 selected SCT. However, several studies have suggested there is more profound immunodeficiency early in the CD34 selected population compared with the unselected population. We encountered two fatal cases of CMV pneumonia at the CD34 selected SCT for T-cell lymphoblastic lymphoma and high-risk breast cancer that was confirmed through a lung biopsy and bronchoalveolar lavage. In conclusion, autologous CD34 selected CMV seropositive recipients need to be monitored in a similar manner to allogeneic recipients.

REFERENCES

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Fig. 1
There noted infiltration of fibrin along alveolar inner wall with cells that have nucleus and marked nucleoli (H& E stain, ×400).
kjh-41-134f1.tif
Fig. 2
Immunohistochemical stain showed nucleus and cytoplasm infected by CMV (Immunohistochemical stain for CMV, ×400).
kjh-41-134f2.tif
Fig. 3
The consolidation was seen on the upper lobe of right lung field on day 70 post transplant.
kjh-41-134f3.tif
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