Two Cases of Cytomegalovirus Pneumonia after CD34 Selected Autologous Stem Cell Transplantation

Young Lan Kwon; Jae Kwon Joeng; Ga Young Kim; Sae Rom Kim; Se Young Lee; Young Deuk Youn; Jung Lim Lee; Won Sik Lee; Gun Young Kwon; Jae Hoo Park

doi:10.5045/kjh.2006.41.2.134

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Kwon, Joeng, Kim, Kim, Lee, Youn, Lee, Lee, Kwon, and Park: Two Cases of Cytomegalovirus Pneumonia after CD34 Selected Autologous Stem Cell Transplantation

Case Report

Korean J Hematol 2006;41(2):134-137.

Published online: 19 June 2006

DOI: https://doi.org/10.5045/kjh.2006.41.2.134

Two Cases of Cytomegalovirus Pneumonia after CD34 Selected Autologous Stem Cell Transplantation

Young Lan Kwon, M.D.¹, Jae Kwon Joeng, M.D.¹, Ga Young Kim, M.D.¹, Sae Rom Kim, M.D.¹, Se Young Lee, M.D.¹, Young Deuk Youn, M.D.¹, Jung Lim Lee, M.D.^1,, Won Sik Lee, M.D.¹, Gun Young Kwon, M.D.², Jae Hoo Park, M.D.³

¹Department of Internal Medicine, Daegu Fatima Hospital, Ulsan, Korea

²Department of Pathology, Dongsan Medical Center, Deagu, Korea

³Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea

Correspondence to : Jung Lim Lee, M.D. Department of Internal Medicine, Daegu Fatima Hospital 302-1 Sinam-dong, Dong-gu, Daegu 701-600, Korea Tel: +82-53-940-7450, Fax: +82-53-954-7417 E-mail: JLLEE3@kornet.net

Received 17 March 2006 Revised 21 May 2006 Accepted 18 June 2006

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cytomegalovirus (CMV) pneumonia is an important cause of treatment related mortality after allogeneic stem cell transplantation (SCT) and autologous SCT, particularly in a CD34 selected setting. There is little known about the immune reconstitution pertaining to the CMV after CD34 selected SCT. However, several studies have suggested there is more profound immunodeficiency early in the CD34 selected population compared with the unselected population. We encountered two fatal cases of CMV pneumonia at the CD34 selected SCT for T-cell lymphoblastic lymphoma and high-risk breast cancer that was confirmed through a lung biopsy and bronchoalveolar lavage. In conclusion, autologous CD34 selected CMV seropositive recipients need to be monitored in a similar manner to allogeneic recipients.

Keywords: CMV pneumonia, CD34 selected stem cell transplantation, T-cell lymphoblastic lymphoma, Breast cancer

REFERENCES

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Fig. 1

There noted infiltration of fibrin along alveolar inner wall with cells that have nucleus and marked nucleoli (H& E stain, ×400).

Fig. 2

Immunohistochemical stain showed nucleus and cytoplasm infected by CMV (Immunohistochemical stain for CMV, ×400).

Fig. 3

The consolidation was seen on the upper lobe of right lung field on day 70 post transplant.

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