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Choi, Park, Jang, Park, Son, Son, Sung, Kim, and Cho: Multicentric melanotic neuroectodermal tumor of infancy: a case report
Original Article

J Korean Assoc Oral Maxillofac Surg 2010;36(5):434-437.

Published online: 10 January 2010

DOI: https://doi.org/10.5125/jkaoms.2010.36.5.434

Multicentric melanotic neuroectodermal tumor of infancy: a case report

Byoung-Hwan Choi1, Su-Won Park1, Soo-Mi Jang1, Bong-Chan Park1, Han-Na Son1, Jang-Ho Son1, Iel-Yong Sung1, Jong-Ryoul Kim2, Yeong-Cheol Cho1

1Department of Oral and Maxillofacial Surgery, College of Medicine, University of Ulsan, Ulsan, Korea

2Department of Oral and Maxillofacial Surgery, Onhospital, Busan, Korea

Yeong-Cheol Cho Department of Oral and Maxillofacial Surgery, Ulsan university hospital 290-3 Jeonha-dong Dong-gu, Ulsan 682-714, Korea Tel: +82-52-250-7230 Fax: +82-52-250-7236 E-mail: lovenip@mail.ulsan.ac.kr

Received 14 July 2010       Revised 20 October 2010       Accepted 22 October 2010

Copyright © 2010 Korean Association of Oral and Maxillofacial Surgeons

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A melanotic neuroectodermal tumor of infancy (MNTI) is a uncommon osteolytic pigmented neoplasm that primarily affects the jaws of newborn infants. Most patients (> 90%) present with the tumor in the first year of life. Approximately 65% form in the maxilla, 11% in the mandible, 5% in the brain and elsewhere. MNTI is normally benign, but up to 15% may recur and a few have metastasized. Approximately 200 cases of MNTI have been reported but only 2 of them presented as multifocal. A case of MNTI in a 7 month old boy was encountered. The chief complaint was maxillary anterior ridge swelling. The incisional biopsy findings were MNTI. Two months after the first operation, mild swelling of another site was observed. The infant was examined periodically since undergoing two procedures with no recurrence. This case demonstrates the possibility of a multicentric MNTI. We report a multicentric MNTI with a review of the relevant literature.

Keywords: Melanotic neuroectodermal tumor of infancy (MNTI), Multicentric

References

1. Johnson RE, Scheithauer BW, Dahlin DC. Melanotic neuroectodermal tumor of infancy. A review of seven cases. Cancer. 1983; 52:661–6.
crossref
2. Lopez J Jr. Melanotic neuroectodermal tumor of infancy: review of the literature and report of a case. J Am Dent Assoc. 1976; 93:1159–64.
3. Krompecher E. Zur Histogenese und Morphologie der Adamantinome und sonstiger Kiefergeschwulste. Beitr Pathol Anat Allg Pathol. 1918; 64:165–97.
4. Borello ED, Gorlin RJ. Melanotic neuroectodermal tumor of infancy-a neoplasm of neural crese origin. Report of a case associated with high urinary excretion of vanilmandelic acid. Cancer. 1966; 19:196–206.
5. Koudstaal J, Oldhoff J, Panders AK, Hardonk MJ. Melanotic neuroectodermal tumor of infancy. Cancer. 1968; 22:151–61.
crossref
6. Lee CH, Hong SP, Lim CY, Chi JG. Melanotic neuroectodermal tumor of infancy. J Korean Med Sci. 1986; 1:63–7.
crossref
7. Navas palacios JJ. Malignant melanotic neuroectodermal tumor: light and electron microscopic study. Cancer. 1980; 46:529–36.
crossref
8. Stowens D, Lin TH. Melanotic progonoma of the brain. Hum Pathol. 1974; 5:105–13.
crossref
9. Block JC, Waite DE, Dehner LP, Leonard AS, Ogle RG, Gatto DJ. Pigmented neuroectodermal tumor of infancy. An example of rarely expressed malignant behavior. Oral Surg Oral Med Oral Pathol. 1980; 49:279–85.
10. Oruckaptan HH, Soylemezoglu F, Kutluk T, Akalan N. Benign melanotic tumor in infancy: discussion on a rare case and review of the literature. Pediatr Neurosurg. 2000; 32:240–7.
11. Cawson RA, Binnie WH, Barret AW, Wright JM. Oral disease. 3rd ed.London: Mosby;2001.
12. Steinberg B, Shuler C, Wilson S. Melanotic neuroectodermal tumor of infancy: evidency for multicentricity. Oral Surg Oral Med Oral Pathol. 1988; 66:666–9.
13. Jones P, Williams A. A case of multicentric melanotic adamantinomata. Br J Surg. 1960; 48:282–5.
14. Nagase M, Ueda K, Fukushima M, Nakajima T. Recurrent melanotic neuroectodermal tumour of infancy. Case report and survey of 16 cases. J Maxillofac Surg. 1983; 11:131–6.
15. Puchalski R, Shah UK, Carpentieri D, McLaughlin R, Handler SD. Melanotic neuroectodermal tumor of infancy (MNTI) of the hard palate: presentation and management. Int J Pediatr Otorhinolaryngol. 2000; 53:163–8.
crossref
16. Hoshina Y, Hamamoto Y, Suzuki I, Nakajima T, Ida-Yonemochi H, Saku T. Melanotic neuroectodermal tumor of infancy in the mandible: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000; 89:594–9.
crossref
17. Mosby EL, Lowe MW, Cobb CM, Ennis RL. Melanotic neuroectodermal tumor of infancy: review of the literature and report of a case. J Oral Maxillofac Surg. 1992; 50:886–94.
crossref
18. Slootweg PJ. Heterologus tissue elements in melanotic neuroectodermal tumor of infancy. J Oral Pathol Med. 1992; 21:90–2.

Fig. 1.
Clinical photograph showing swelling on left anterior alveolus.
jkaoms-36-434f1.tif
Fig. 2.
Axial computed tomography (CT) of patient showing radiolucent lesion expanding into labial and palatal direction.
jkaoms-36-434f2.tif
Fig. 3.
Intraoperative photograph of the resected tumor.
jkaoms-36-434f3.tif
Fig. 4.
Clinical photograph showing on right anterior alveolus at 2 months after first operation.
jkaoms-36-434f4.tif
Fig. 5.
Clinical photograph after second operation. There was no recurrence.
jkaoms-36-434f5.tif
Fig. 6.
Histopathologic findings of the primary operation showing tumor cells composed of small neuroblastic cells and larger melanin containing epithelial cells.(H&E staining, original magnification ×100)
jkaoms-36-434f6.tif
Fig. 7.
Histopathologic findings of the secondary operation showing similar features with primary operation.(H&E staining, original magnification ×100)
jkaoms-36-434f7.tif
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