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Journal List > J Korean Assoc Oral Maxillofac Surg > v.36(5) > 1032421

Kwak, Jang, Kim, Kim, and Kim: The clinical study on the sedative effect and recovery in patients undergoing intravenous conscious sedation with midazolam for mandibular third molars extraction

Abstract

Introduction

This study examined the depth of sedation and the usefulness of the monitoring tool in determining the level of sedation in patients undergoing third molars extraction under conscious sedation with midazolam.

Materials and Methods

Twenty two patients undergoing third molars extraction at the department of Oral and Maxillofacial surgery, Ewha Womans Mokdong Hospital from February 2010 to April 2010 were analyzed. All patients were classified as American Society of Anesthesiologist (ASA) class I and had no contraindications tosedation. The bispectral index was recorded continually during surgery using a bispectral monitor. The initial sedation was accomplished using a 3 mg bolus of midazolam followed by a 2 mg bolus of midazolam until the level of sedation, at which the patient's eyes were closed or the subject was responsive only to loud or repeated calling of their name, was reached. All subjects were surveyed with a postoperative questionnaire to evaluate the level of sedation.

Results

The bispectral index (BIS) decreased approximately 5 minutes after midazolam administration, but increased at the local anesthesia injection and odontomy procedure. The amnestic effect was shown effectively in the early stages of surgery.

Conclusion

Conscious sedation with intravenous midazolam is effective in achieving the effect of anxiolysis, analgesia and amnesia. The BIS is an objective and useful means of assessing the depth of sedation.

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jkaoms-36-408f1.tif
Fig. 1.
The change of blood pressure in the times of the study (mmHg). (SBP: systolic blood pressure, DBP: diastolic blood pressure)
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Fig. 2.
The change of heart rate in the times of the study (BPM).
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Fig. 3.
The change of respiratory rate in the times of the study (BPM).
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Fig. 4.
The change of BIS values in the times of the study (values).
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jkaoms-36-408f5.tif
Fig. 5.
Amnesia incidence according to stimulation or procedure after administration of midazolam.
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Fig. 6.
Magnitude of amnesia: number of memory object words recalled/recognized after 3 hours sedation sessions.
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jkaoms-36-408f7.tif
Fig. 7.
VAS score of anxiolysis and pain perception per patient (VAS: visual analogue scale): the evaluation of the anxiolytic and sedative effects of the employed sedation procedures was made through the VAS score. The amount of anxiolytic effect and pain that a patient feels ranges across a continuum from none to an extreme amount of anxiolysis and pain, with higher score indicating favorable preference on anxiolysis and unfavorable preference on pain.
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jkaoms-36-408f8.tif
Fig. 8.
Satisfaction degree of patients and surgeon: by assigning the following scores to the corresponding answers. (1: very unsatisfactory, 2: unsatisfactory, 3: intermediate, 4: satisfactory, 5: very satisfactory) Questionnaire responses score 1–5, with higher score indicating favorable preference.
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Table 1.
Patients'characteristics
Mean age (years) 22.18±5.77 (SD)
Range of Age (years) 17–38
Gender (male/female) 12/10
Operation time (minute) 37.41±11.05
BMI (kg/m2) 21.91±3.57

(SD: standard deviation, BMI: body mass index)

Table 2.
Patients'characteristics according to gender
  Mean age (years) Height (cm) Weight (kg)
Male 24.17±7.00 178.25±4.45 74.42±11.47
Female 19.80±2.49 163.60±5.28 53.00±7.34

Mean±SD

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