Expression of osteoclastogenesis related factors in dental implant patients

Seong-Hee Ryu; Bang-Sin Kim; Seunggon Jung; Man-Seung Han; Min-Suk Kook; Seung-Ho Ohk; Hee-Kyun Oh; Hong-Ju Park

doi:10.5125/jkaoms.2010.36.5.386

Journal List > J Korean Assoc Oral Maxillofac Surg > v.36(5) > 1032417

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Ryu, Kim, Jung, Han, Kook, Ohk, Oh, and Park: Expression of osteoclastogenesis related factors in dental implant patients

Original Article

J Korean Assoc Oral Maxillofac Surg 2010;36(5):386-390.

Published online: 10 January 2010

DOI: https://doi.org/10.5125/jkaoms.2010.36.5.386

Expression of osteoclastogenesis related factors in dental implant patients

Seong-Hee Ryu^1,³, Bang-Sin Kim^1,³, Seunggon Jung^1,³, Man-Seung Han^1,³, Min-Suk Kook^1,³, Seung-Ho Ohk^2,³, Hee-Kyun Oh^1,³, Hong-Ju Park^1,³

¹Department of Oral and Maxillofacial Surgery, Dental Science Research Institute, Gwangju, Korea

²Oral Microbiology, School of Dentistry, Dental Science Research Institute, Gwangju, Korea

³2nd stage of Brain Korea 21 (BK21), Chonnam National University, Gwangju, Korea

Hong-Ju Park Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University 5 Hak-Dong, Dong-Ku, Gwangju, 501-757, Korea Tel: +82-62-220-5439 Fax: +82-62-228-8712 E-mail: omspark@chonnam.ac.kr

Received 4 June 2010 Revised 12 October 2010 Accepted 15 October 2010

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction

Bone resorption is a unique function of osteoclasts. Osteoclasts are a specialized macrophage polykaryon whose differentiation is regulated principally by macrophage colony-stimulating factors, receptor activator of nuclear factor κ B ligand (RANK) ligand, osteoprotegerin (OPG), and interleukins (IL). Reflecting the integrin-mediated signals, osteoclasts develop a specialized cytoskeleton that allows it to establish an isolated microenvironment between itself and the bone, wherein matrix degradation occurs by a process involving proton transport. The levels of IL-1, IL-6, OPG, and prostaglandin E2 (PGE2) expression were evaluated to study the correlations between dental implant teeth and the adjacent teeth.

Materials and Methods

The exudate of the gingival crevice acquired from dental implants, adjacent teeth, opposite teeth and contralateral teeth of 24 patients.

Results

1. The levels of IL-1, IL-6, OPG and PGE2 expression in dental implant teeth were higher than those of the contralateral teeth. 2. IL-1 revealed a higher expression level in the adjacent teeth than in dental implant teeth. 3. The dental implant teeth and adjacent teeth did not show a remarkable difference in the level of IL-1 expression. 4. All the other cytokines were strongly expressed in the dental implant compared to the adjacent teeth.

Conclusion

These results suggest that there might be close correlation between dental implant teeth and adjacent teeth in terms of the expressions of cytokines that affect the development and regulation of osteoclasts.

Keywords: Dental implants, Cytokines, Osteoclasts

References

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Fig. 1.

Expression of interleukin-1 α(IL-1 α) in dental implant patients. (I: dental implant teeth, A: adjacent teeth to the dental implant, O: opposite, N: normal teeth)

Fig. 2.

Expression of interleukin-1 β(IL-1 β) in dental implant patients. (I: dental implant teeth, A: adjacent teeth to the dental implant, O: opposite, N: normal teeth. 1: P<0.01, 2: P<0.01)

Fig. 3.

Expression of interleukin-6 (IL-6) in dental implant patients. (I: dental implant teeth, A: adjacent teeth to the dental implant, O: opposite, N: normal teeth)

Fig. 4.

Expression of osteoprotegerin (OPG) in dental implant patients. (I: dental implant teeth, A: adjacent teeth to the dental implant, O: opposite, N: normal teeth. 1: P<0.01, 2: P<0.01)

Fig. 5.

Expression of prostaglandin E2 (PGE2) in dental implant patients. (I: dental implant teeth, A: adjacent teeth to the dental implant, O: opposite, N: normal teeth. 1: P<0.01, 2: P<0.01)

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