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Park, Seok, Choi, Kim, Lim, Yoon, Kim, Kim, and Park: Salmonella enterica Serovar London Infections Associated with Consumption of Infant Formula
Original Article
Yonsei Medical Journal

Yonsei Medical Journal 2004; 45(1): 43-48.

Published online: 28 February 2004

DOI: https://doi.org/10.3349/ymj.2004.45.1.43

Salmonella enterica Serovar London Infections Associated with Consumption of Infant Formula

Jong Ku Park1, Won Seok Seok5, Byoung Joo Choi6, Hwang Min Kim2, Baek Keun Lim2, Sung Sik Yoon4, Shukho Kim7, Young Soo Kim5, Joo Young Park3

1Department of Preventive Medicine, Wonju College of Medicine, Yonsei University, Gangwon-do, Korea.

2Department of Pediatrics, Wonju College of Medicine, Yonsei University, Gangwon-do, Korea.

3Department of Microbiology, Wonju College of Medicine, Yonsei University, Gangwon-do, Korea.

4Department of Biological Resources and Technology, Yonsei University, Wonju, Korea.

5Research Institute of Health & Environment, Gangwon-Do, Korea.

6Environment & Welfare Bureau, Gangwon-Do, Korea.

7Korea National Institute of Health, Seoul, Korea.

Reprint address: requests to Won-Seok Seok, Ph.M., Gangwon-do Research Institute of Health & Environment, 728 Sancholli, Shinbuk-Eup, Chuncheon, Gangwon-do 200-822, Korea. Tel: 82-33-250-1711, Fax: 82-33-250-1716, doldario@provin.gangwon.kr

Received 22 October 2002       Accepted 17 October 2003

Copyright © 2004 The Yonsei University College of Medicine

Abstract

Epidemiologic studies were conducted on 31 cases of Salmonella group E infection detected in 2000 through a laboratory-based pathogen surveillance in Gangwon Province, Korea. Data were collected on the environmental exposures and the patients' foods, including the brand (s) of milk consumed before the onset of diarrhea. The patients' medical records were also reviewed. All of the patients were infants under 10 months of age except one 7-year old child.
Surprisingly, all of the infants were fed with infant formulas from Company A, although two infants were fed with infant formulas from both Company A and Company B. Antimicrobial susceptibility test and pulsed-field gel electrophoresis (PFGE) were performed in 25 out of 31 isolates from the patients and in 1 isolate from an opened packet of infant formula collected from the home of an infected infant. All of the 26 isolates were Salmonella enterica serovar London. They showed a single PFGE pattern, and all of the isolates were susceptible to the 18 antibiotics tested. The causative agent of the salmonella outbreaks in the Gangwon Province and its surrounding areas was Salmonella London, and the highly likely source of the infection was infant formula from Company A.

Keywords: Salmonellosis, infant, formula, Korea

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