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Seymen, Civelek, Seven, Yiğit, Hatemi, and Burçak: Iron Supplementation in Experimental Hyperthyroidism: Effects on Oxidative Stress in Skeletal Muscle Tissue
Original Article
Yonsei Medical Journal

Yonsei Medical Journal 2004; 45(3): 413-418.

Published online: 17 February 2009

DOI: https://doi.org/10.3349/ymj.2004.45.3.413

Iron Supplementation in Experimental Hyperthyroidism: Effects on Oxidative Stress in Skeletal Muscle Tissue

Hakki Oktay Seymen1, Sabiha Civelek2, Arzu Seven2, Günnur Yiğit1, Hüsrev Hatemi3, Gülden Burçak2

1Department of Physiology, Cerrahpaa Medical Faculty, Istanbul University, Istanbul, Turkey.

2Department of Biochemistry, Cerrahpaa Medical Faculty, Istanbul University, Istanbul, Turkey.

3Department of Internal Medicine, Cerrahpaa Medical Faculty, Istanbul University, Istanbul, Turkey.

Reprint address: requests to Dr. Hakki Oktay Seymen, Barbaros mah. Sedef Sok. Onur Sitesi, 9/23 Uskudar, Istanbul, Turkey 81150. Tel: 90-212-4143000/1572, Fax: 90-212-4143072, seymano@yahoo.com

Received 9 September 2003       Accepted 13 December 2003

Copyright © 2004 The Yonsei University College of Medicine

Abstract

This study was designed to investigate the effects of iron supplementation on the parameters of oxidative stress in the skeletal muscle tissue of hyperthyroidism induced rats. Hyperthyroidism was found to cause an increase in thiobarbituric acid-reactive substances (TBARS) and copper zinc superoxide dismutase (Cu, Zn SOD) activity, but decreases in the glutathione-peroxidase (GSH Px) activity and glutathione (GSH). Iron supplementation caused an increase in TBARS and a decrease in GSH. Iron supplementation in hyperthyroid rats attenuated the hyperthyroid state, but lowered the plasma ferritin level, which is considered an indicator of thyroid hormone action. Iron supplementation caused no additional increase in the TBARS in hyperthyroid rats, ameliorated the decrease in GSH content and abolished the induction of Cu, Zn SOD.
Our findings suggested no increase, but a decrease, in the risk of oxidative stress in iron supplemented hyperthyroid rats. Whether supplementation of iron would have similar effects in humans should be further investigated in clinical studies.

Keywords: Hyperthyroidism, iron supplementation, skeletal muscle, lipid peroxidation, antioxidant status, ferritin

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