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Orbak, Selimoglu, and Doneray: Inherited Vitamin K Deficiency: Case Report and Review of Literature
Case Report
Yonsei Medical Journal

Yonsei Medical Journal 2003; 44(5): 923-927.

Published online: 30 March 2009

DOI: https://doi.org/10.3349/ymj.2003.44.5.923

Inherited Vitamin K Deficiency: Case Report and Review of Literature

Zerrin Orbak1, Ayse Selimoglu2, Hakan Doneray3

1Department of Pediatrics, Atatürk University Faculty of Medicine, Erzurum, Turkey.

2Department of Pediatric Gastroenterology, Atatürk University Faculty of Medicine, Erzurum, Turkey.

3Department of Pediatrics, Atatürk University Faculty of Medicine, Erzurum, Turkey.

Reprint address: requests to Dr. Zerrin Orbak, Department of Pediatrics, Ataturk Universitesi Dis Hekimligi Fakultesi, Periodontoloji Anabilim Dali, 25240 Erzurum, Turkey. Tel: 90-442-2313926, Fax: 90-442-2361301, zerrinorbak@yahoo.com

Received 15 May 2002       Accepted 22 January 2003

Copyright © 2003 The Yonsei University College of Medicine

Abstract

Vitamin K is the cofactor for the hepatic carboxylation of glutamic acid residues in a number of proteins including the procoagulants factors ll, Vll, lX, and X. The role of vitamin K in normal bone function is not fully understood. Inherited deficiency of vitamin K dependent coagulation factors is a rare bleeding disorder reported only in a few patients. Here we present an 18-month old child who presented with osteopeni due to inherited vitamin K deficiency.
While the patient had high bone specific alkaline phosphatase and parathyroid hormone levels and low osteocalcin and bone mineral density values, with the regular supplementation of vitamin K all the mentioned parameters returned to normal values.

Keywords: Hereditary vitamin K deficiency, osteopenia, treatment, osteocalcin

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