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Park, Park, Hahn, Kim, Lee, Noh, and Suh: Low Grade MALT Lymphoma of the Stomach: Treatment Outcome with Radiotherapy Alone
Original Article
Yonsei Medical Journal

Yonsei Medical Journal 2002; 43(5): 601-606.

Published online: 1 April 2009

DOI: https://doi.org/10.3349/ymj.2002.43.5.601

Low Grade MALT Lymphoma of the Stomach: Treatment Outcome with Radiotherapy Alone

Hee Chul Park1, Won Park1, Jee Sook Hahn2, Choong Bae Kim3, Yong Chan Lee2, Jae Kyoung Noh2, Chang Ok Suh1

1Department of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Center, Seoul, Korea.

2Department of Internal Medicine, Yonsei University College of Medicine, Yonsei Cancer Center, Seoul, Korea.

3Department of Surgery, Yonsei University College of Medicine, Yonsei Cancer Center, Seoul, Korea.

Reprint address: requests to Dr. Chang Ok Suh, Department of Radiation Oncology, Yonsei University College of Medicine, C.P.O. Box 8044, Seoul 120-752, Korea. Tel: 82-2-361-7631, Fax: 82-2-312-9033, therapy@yumc.yonsei.ac.kr

Received 16 March 2002       Accepted 5 August 2002

Copyright © 2002 The Yonsei University College of Medicine

Abstract

In order to evaluate the role of radiation therapy in the management of low-grade mucosa-associated lymphoid tissue lymphoma of the stomach (MLS), in patients with no evidence of Helicobacter pylori (H. pylori) or who had not responded to H. pylori eradication treatment, we analyzed the treatment outcome of patients who had received radiotherapy alone.
Between Jan 1995 and May 2001, 6 patients with low-grade MLS were treated with radiotherapy alone. The median radiation dose was 30.6 Gy (range; 30 - 39 Gy) in a daily fractions of 1.5 - 1.8 Gy. Each patient had an endoscopic esophago-gastro-duodenoscopy with biopsy, 4 weeks after the completion of radiotherapy and every 6 months thereafter.
A complete response was obtained in all patients. All patients were followed-up without evidence of disease, and no patient suffered a relapse. There was neither perforation nor hemorrhage of the stomach in any of the patients. No renal or hepatic toxicity were noted, and no secondary malignancies developed.
In conclusion, radiotherapy should be considered as the preferred treatment method for low-grade MLS, in patients with no evidence of H. pylori infection, or who do not respond to antibiotic therapy, due to the significant benefits in gastric preservation and low morbidity.

Keywords: Stomach, lymphoma, mucosa-associated lymphoid tissue, Helicobacter pylori, radiotherapy, organ preservation

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