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Lee, Ha, Ryu, Moon, Im, Kim, and Kim: Assignments of the tyrosinase related protein-1 and -2 genes to human chromosome bands 9p23 and 13q32.1 by in situ hybridization
Original Article
Yonsei Medical Journal

Yonsei Medical Journal 2000; 41(3): 398-400.

Published online: 7 April 2009

DOI: https://doi.org/10.3349/ymj.2000.41.3.398

Assignments of the tyrosinase related protein-1 and -2 genes to human chromosome bands 9p23 and 13q32.1 by in situ hybridization

Young Mi Lee1, Mahn Joon Ha1, Min Sook Ryu2, Eunpyo Moon2, Sungbin Im3, Hyon Ju Kim1, Wankee Kim1

1Institute for Medical Sciences, College of Natural Sciences, Ajou University, Suwon, Korea.

2Department of Dermatology, School of Medicine, Ajou University, Suwon, Korea.

3Department of Biological Sciences, College of Natural Sciences, Ajou University, Suwon, Korea.

Address reprint requests to Dr. W. Kim, Institute for Medical Sciences, School of Medicine, Ajou University, Suwon 442-749, Korea. Tel: 82-331-219-4506, Fax: 82-331-219-4503, wkim@madang.ajou.ac.kr

Received 13 November 1999       Accepted 25 February 2000

Copyright © 2000 The Yonsei University College of Medicine

Abstract

To determine the precise chromosomal localization of tyrosine related protein-1 and -2 (TRP-1 and TRP-2) genes by fluorescence in situ hybridization, we used DNAs isolated from human bacterial artificial chromosome clones. They contain genomic sequences with approximately 120 kb inserts for TRP-1 and TRP-2. The TRP-1 and TRP-2 genes were assigned to human chromosome bands 9p23 and 13q32.1, respectively. These results confirmed the previously mapped location for the TRP-1 gene and more precisely located the TRP-2 gene, which had previously been mapped to chromosome 13q31-q32.

Keywords: Tyrosine related proteins, bacterial artificial chromosome library, fluorescence in situ hybridization

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