Journal List > Yonsei Med J > v.34(4) > 1028645

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Cheon, Sohn, Chang, Kim, Ko, Kim, Lee, Lee, Shin, Jeong, and Chung: Flow cytometric analysis of DNA ploidy in primary non-small cell carcinoma of the lung in Korea
Original Article
Yonsei Medical Journal

Yonsei Medical Journal 1993; 34(4): 365-370.

Published online: 20 February 2002

DOI: https://doi.org/10.3349/ymj.1993.34.4.365

Flow cytometric analysis of DNA ploidy in primary non-small cell carcinoma of the lung in Korea

Seon Hee Cheon, Hee Young Sohn, Joon Chang, Se Kyu Kim, Eun Hee Ko, Sung Kyu Kim, Won Young Lee, Doo Yun Lee, Dong Hwan Shin, Eun Taik Jeong, Hun Taeg Chung

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, Korea.

Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

Department of Internal Medicine, Won Kwang University College of Medicine, Iri, Korea.

Department of Immunology, Won Kwang University College of Medicine, Iri, Korea.

Copyright © 1993 The Yonsei University College of Medicine

Abstract

Flow cytometrically determined nuclear DNA content has been measured on 74 formalin-fixed, paraffin embedded specimens of non-small cell carcinoma of the lung. Of the 60 tumors that were successfully analyzed, 32 (53%) were diploid and 28 (47%) were aneuploid. The mean DNA index of aneuploid tumor was 1.5 ± 0.25, ranging from 1.1 to 2.0. There was no significant correlation between DNA ploidy and the patient's clinical characteristics, histology of tumor, nodal status or tumor stage. Tumor ploidy was not found as a prognostic determinant in non-small cell carcinoma of the lung in this study.

Keywords: Flow cytometry, ploidy, non-small cell carcinoma, lung

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