Journal List > Yonsei Med J > v.34(4) > 1028638

TOOLS
Saito, Moritoyo, Park, Lee, Kim, Fujisawa, Osame, and Yoshida: Nucleotide sequence analysis of HTLV-I isolate from a Korean patient with HAM/TSP
Original Article
Yonsei Medical Journal

Yonsei Medical Journal 1993; 34(4): 321-327.

Published online: 20 February 2002

DOI: https://doi.org/10.3349/ymj.1993.34.4.321

Nucleotide sequence analysis of HTLV-I isolate from a Korean patient with HAM/TSP

Mineki Saito, Takashi Moritoyo, Jae Hyeon Park, Byung In Lee, Jin Soo Kim, Jun ichi Fujisawa, Mitsuhiro Osame, Mitsuaki Yoshida

Department of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minatoku, Tokyo, Japan.

Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.

Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.

Copyright © 1993 The Yonsei University College of Medicine

Abstract

Limited nucleotide sequences of human T-cell lymphotropic virus type I (HTLV-1) provirus isolated from the first case of a Korean patient with HTLV-I associated myelopathy and tropical spastic paraparesis (HAM/TSP) were analysed and compared with other isolates from different regions of the world. The sequences of the env, LTR regions (536bp, 690bp respectively) showed 98.7%, 99.3% homologies with the prototype HTLV-I, ATK-1, isolated from a Japanese Adult T-cell leukemia (ATL) patient. A comparison between other isolates from different geographical origins revealed that the Korean HTLV-I isolate is more closely related to Japanese isolates than to those from other geographical origins

Keywords: HTLV-I, HAM/TSP, polymerase chain reaction, nucleotide sequence analysis

TOOLS
Similar articles