Journal List > Yonsei Med J > v.33(4) > 1028599

Lee, Kim, Lee, Yoon, Kim, Kim, Jung, Chung, Lim, Lee, and Huh: Thyrotropin-secreting pituitary microadenoma


We present a 45-yr-old male with clinical signs and symptoms of mild hyperthyroidism, high serum levels of T3, T4, and FT4 as well as serum TSH concentration. The elevated α-subunit level and α-subunit/TSH molar ratio were also observed. These findings indicated the presence of hyperthyroidism due to inappropriate secretion of TSH, whose neoplastic origin was documented by nuclear magnetic resonance scan showing a 0.6 cm pituitary adenoma. Selective pituitary adenomectomy was completely successful; α-subunit, TSH, T3, T4, and FT4 normalized, and euthyroidism was restored. Light microscopic immunohistochemistry showed that the adenoma was composed of TSH-secreting cells

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