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Kim, Youn, Kim, and Kim: Natural Killer Cell Activity in Rheumatoid Arthritis Measured by a Single Cell Cytotoxicity Assay
Original Article
Yonsei Medical Journal

Yonsei Medical Journal 1988; 29(2): 160-165.

Published online: 20 February 2002

DOI: https://doi.org/10.3349/ymj.1988.29.2.160

Natural Killer Cell Activity in Rheumatoid Arthritis Measured by a Single Cell Cytotoxicity Assay

Gye Sung Kim1, Jung Koo Youn1, Joo Deuk Kim1, Nam Hyun Kim2

1Department of Microbiology, Yonsei University, College of Medicine, Seoul, Korea.

2Department of Orthopedic Surgery, Yonsei University, College of Medicine, Seoul, Korea.

Received 8 May 1988       Accepted 1 April 1988

Copyright © 1988 The Yonsei University College of Medicine

Abstract

The natural killer(NK) cell activity of mononuclear cells (MNC) from peripheral blood (PB) and synovial fluid (SF) of 40 rheumatoid arthritis(RA) patients was investigated by employing 51-chromium-(51Cr) release microcytotoxicity and single cell cytotoxicity assays against K562 target cells. It has been revealed that SF-MNC from RA patients showed a significantly lower NK activity than PB-MNC from the same patients and this might be due to an impaired target binding capacity of the effector cells and not due to a deficiency of active NK cells.

Keywords: Rheumatoid arthritis, NK cells, single cell cytotoxicity

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