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Min, Ban, Kim, Kim, and Ryu: Distribution of 5-Fluorouracil-14C in Body Tissues after Systemic and Regional Administration in Gastric Cancer
Original Article
Yonsei Medical Journal

Yonsei Medical Journal 1986; 27(3): 200-204.

Published online: 20 February 2002

DOI: https://doi.org/10.3349/ymj.1986.27.3.200

Distribution of 5-Fluorouracil-14C in Body Tissues after Systemic and Regional Administration in Gastric Cancer

Jin Sik Min, Jae Min Ban, Myung Wook Kim, Choon Kyu Kim, Kyung Ja Ryu1

Department of General Surgery, Yonsei Univeristy College of Medicine, Seoul, Korea.

1Department of Pharmacology, Yonsei Univeristy College of Medicine, Seoul, Korea.

Received 30 April 1986       Accepted 2 July 1986

Copyright © 1986 The Yonsei University College of Medicine

Abstract

This study was to determine which of two routes of administration of 5-fluorouracil (5-FU) is more effective, by measuring the radioactvity in the body tissues of gastric cancer patients after the administration of 5-FU-l4C via the systemic intravenous and the regional intra-arterial routes.
After the drug was administered intravenously in one group of patients, and intra-arterially in another; samples of portal venous blood, the liver, the lymph nodes, and the normal and the cancerous tissues of the stomach were obtained. The radioactivities of the samples were measured, and it was found that those of the regional lymph nodes, the liver, and the normal and the cancerous tissues of the stomach were much higher in the latter group. The regional intra-arterial routes is the more effective way to administer 5-FU in patients with stomach cancer.

Keywords: 5-FU, administration, gastric cancer, systemic, regional

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