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Kim, Kang, Han, Kim, and Kim: Auto-immune Response in Degenerated Lumbar Disk
Original Article
Yonsei Medical Journal

Yonsei Medical Journal 1981; 22(1): 26-32.

Published online: 20 February 2002

DOI: https://doi.org/10.3349/ymj.1981.22.1.26

Auto-immune Response in Degenerated Lumbar Disk

Nam Hyun Kim, Eung Shick Kang, Chang Dong Han, Joo Deuk Kim**, Chang Hee Kim**

Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.

**Department of Microbiology, Yonsei University College of Medicine Seoul, Korea.

Received 12 May 1981

Copyright © 1981 The Yonsei University College of Medicine

Abstract

The serum level of Ig G, Ig M, Ig A, Ig D and C3 were determined by a Hyland Immunodiffusion plate in 60 patients and 29 normal healthy controls. Immunoglobulin G level was increased only in patient's with herniated nucleus pulposus.
We also could demonstrate high levels of Ig G in group I, the ruptured nucleus cases, but there were no differences in the levels of other immunoglobulins and C3 in other groups.
In the Ochterlony gel diffusion test for the detection of humoral antibody for the nucleus pulposus, only 4 cases gave precipitation lines using antigen excised from nucleus pulposus. In 2 cases high levels of Ig G were observed. All 89 patients gave negative precipitation lines using proteoglycan as antigen.

Keywords: Disk, Autoimmunity

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