In March 2007, a 65-year-old man with ADPKD, and consequently underwent hemodialysis since June 2001, was admitted to our hospital with symptoms of poor oral intake due to abdominal distention. His daily urine volume was approximately 300 mL and his abdomen was distended, with a maximum circumference of 105 cm. His weight and height were 63.8 kg and 170 cm, respectively. The laboratory findings were as follows: hemoglobin, 11.7 g/dL; albumin, 3.2 g/dL; BUN, 38 mg/dL; creatinine, 6.5 mg/dL; and total cholesterol, 206 mg/dL. A computed tomography (CT) of the abdomen revealed markedly enlarged polycystic kidneys bilaterally and multiple liver cysts. The renal volumes, appearing as an ellipsoid on CT images, were 3,309 mL and 3,173 mL on the right and left sides, respectively, according to the following formula: (π/6) × (length × width × depth).

Written informed consent was obtained from the patient. A TAE was performed in March 2007. This procedure was performed through the right femoral artery using the Seldinger technique, which involved the insertion of a Terumo guide wire (Radiofocus M; Terumo, Tokyo, Japan) and a 5-Fr Cobra catheter (Cook, Bloomington, IN) under local anesthesia. The arteriogram before the renal TAE showed bilateral narrowing (left > right), and stretched the renal arteries. Absolute ethanol was injected via the coaxial catheter (Progreat microcatheter system; Terumo, Tokyo, Japan) into the right renal artery. Seven mL of ethanol with 2 mL of Lipiodol was used to detect reflux of the radiolucent ethanol. After 5 minutes, the right renal artery was completely embolized. At this time, a renal TAE was performed on one side of the kidney only because the patient will only want to repeat the procedure on the contralateral kidney if the results of the first TAE are good. A second TAE of left renal artery was performed in March 2008. The procedure was the same as the previous TAE. At this time, we used a balloon catheter to prevent the reflux of the ethanol. After performing a selective renal arteriography, a 5-mm-diameter, 2-cm-long, 3-Fr balloon catheter (Savvy; Cordis Europe, Roden, The Netherlands) was positioned in the main renal artery. With the balloon inflated, 3 mL of ethanol was slowly injected for complete embolization (Fig. 1A-D).

After the TAE, the patient experienced abdominal and lower back pain, which were ameliorated with opioids (pethidine - 25 mg three times a day for 2 days). The patient developed a fever the next day, which was controlled by a non-steroidal anti-inflammatory agent. He recovered and was discharged three days after the TAE. The poor oral intake due to abdominal distention was relieved one month after the TAE. Over the course of an 18 month follow-up period, the patient's general condition improved. His kidney size decreased bilaterally after the TAE (Fig. 1E, F). The abdominal maximum circumference was reduced from 105 to 80 cm. The patient's dry weight decreased from 63 to 58 kg and hypertension did not develop. The daily 300 mL urine output did not change. The patient's serum hemoglobin and cholesterol levels did not change, but the albumin level increased slightly (Fig. 1G). In summary, the patient experienced no recurrent symptoms or complications at 18 months after treatment.

In 1980, Harley et al. (8) described the TAE technique with a Gianturco-Wallace coil to control recurrent hemorrhage in patients with ADPKD. In 1999, Ubara et al. (9) reported a successful case involving a patient on long-term hemodialysis therapy in whom a TAE of the renal arteries reduced the size of the enlarged kidneys. Ubara et al. (6) evaluated the effectiveness of TAEs with metallic coils in 64 patients with ADPKD. Renal contraction therapy by TAE with metallic coils is effective in decreasing renal size, but great care is needed not to drop the coil into the abdominal aorta and many coils are needed to embolize the renal arteries. Further, there is a possibility of recanalization caused by the migration of coils. Sakuhara et al. (10) reported a case of a TAE performed in combination with ethanol injection for enlarged polycystic kidneys. In this case, the administration of ethanol was shown to be effective in embolizing the peripheral arteries through the recanalized arteries in which the coils had been placed. Ethanol induces complete cellular death with total vascular occlusion and necrosis of perivascular areas, thereby avoiding late revascularization by collateral vessels (11). Contraction of the cystic volume with ethanol occurs by the necrosis of perivascular areas due to the extensive capillary network within the polycystic kidney wall (12). Therefore, we performed a TAE using ethanol in ADPKD patients. Our case is the second reported case of performing a TAE with ethanol in ADPKD patients. But our case is unique in that we attempted a TAE with ethanol to embolize the renal arteries without previous treatment such as coil embolization, and our patient was followed up for 18 months, which was longer than the previous reported case.

A renal TAE with ethanol has been used for other renal diseases such as the ablation of renal masses. In general, renal ethanol embolization can be safely performed, but there are rare reported complications, such as testicular or colonic infarctions (13, 14). These reported complications can be caused by reflux of injected ethanol. To prevent this complication, we used an occlusion balloon catheter (15). The radiolucency of ethanol can lead to this problem (16), thus we used ethanol mixed with contrast media. In the left renal artery TAE, we used a balloon catheter due to severe narrowing of the renal artery and strong blood flow, but we needed a smaller amount of ethanol than in the right renal artery. Despite the small amount of ethanol, the embolization was performed successfully and there was no reflux of ethanol or ensuing complications.

Ubara et al. (6) reported that a renal TAE was performed in each kidney, but not performed at the same time in the first five patients because two of 64 patients experienced hemorrhage in the contralateral kidney after a renal TAE on one side. However, a renal TAE was performed simultaneously on both sides in the remaining 59 patients and there were no further complications. In our case, we performed a renal TAE with an interval, but the renal TAE can be performed simultaneously also.

There were minor complications associated with the TAE in the patient described herein. Namely, abdominal and lower back pain, and a fever, but all symptoms subsided after a short interval with conservative treatment measures. The patient's presenting complaint, abdominal distention, was relieved one month after the TAE. There may have been a relatively rapid reduction of kidney volume in the early period after the TAE, but renal contraction as evidenced on CT images, continued thereafter. In the case of the right kidney, there was a 43% reduction in kidney volume at nine months and 34% at 18 months. In the case of the left kidney, reduction of the kidney volume was 38% at six months. The cause of the rapid reduction in the left kidney volume may reflect the greater narrowing of the left main renal artery compared to the right renal artery. Increased arteriosclerosis of the left renal artery may have accounted for the difference in narrowing. Ubara et al. (6) reported that a renal TAE was especially effective in patients > 60 years of age and/or individuals with severe arteriosclerosis.

In the current case, ethanol was an effective measure for the embolization of the renal artery. A renal TAE with ethanol in our patient was successful, minimally invasive, and showed no serious side effects for 18 months. To prevent complications associated with the reflux of ethanol, the use of a balloon catheter and/or ethanol mixed with contrast media are recommended. Although a long-term follow-up study is necessary, these results suggest that the renal TAE with ethanol injection is another reasonable therapy for patients with ADPKD and nephromegaly.