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Rhee, Jung, Shin, Suh, Noh, Youn, Oh, and Choe: The Effects of Antioxidants and Nitric Oxide Modulators on Hepatic Ischemic-Reperfusion Injury in Rats
Original Article
Journal of Korean Medical Science

Journal of Korean Medical Science 2002; 17(4): 502-506.

Published online: 23 April 2009

DOI: https://doi.org/10.3346/jkms.2002.17.4.502

The Effects of Antioxidants and Nitric Oxide Modulators on Hepatic Ischemic-Reperfusion Injury in Rats

Joong Eui Rhee, Sung Eun Jung, Sang Do Shin, Gil Joon Suh, Dong Young Noh, Yeo Kyu Youn, Seung Keun Oh, Kuk Jin Choe

Department of Emergency Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.

Department of Surgery, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.

sejung@plaza.snu.ac.kr

Copyright © 2002 The Korean Academy of Medical Sciences

Abstract

Ischemic-reperfusion injury (IRI) is thought to be caused by oxygen radicals. Nitric oxide (NO) also has been thought to play a key role in IRI. This experiment was designed to evaluate the effects of antioxidants and NO supplement on hepatic IRI. Male Sprague-Dawley rats were divided into five groups: a sham operation group, a group with IRI, and three groups with vitamin C combined with vitamin E (VC

Keywords: Reperfusion Injury, Nitric Oxide, Antioxidants, Tumor Necrosis Factor, Ascorbic Acid

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