Journal List > J Korean Med Sci > v.15(Suppl) > 1019186

TOOLS
Marunaka, Niisato, and Ito: Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase
Original Article
Journal of Korean Medical Science

Journal of Korean Medical Science 2000; 15(Suppl): S42-S43.

Published online: 25 June 2009

DOI: https://doi.org/10.3346/jkms.2000.15.S.S42

Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase

Yoshinori Marunaka, Naomi Niisato, Yasushi Ito

Department of Physiology, Kyoto Prefectural University of Medicine, Japan.

marunaka@phys.kpu-m.ac.jp

Copyright © 2000 The Korean Academy of Medical Sciences

Abstract

1) A beta agonist stimulated Na+ transport and decreased the intracellular Cl concentration ([Cl]c) associated with cell shrinkage via an increase in cytosolic cAMP level by activating adenylate cyclase in rat fetal distal lung epithelial (FDLE) cells. 2) Lowering [Cl-]c activated a 28-pS nonselective cation (NSC) channel by elongating the open time of the channel. 3) cAMP signals were converted to a protein tyrosine kinase (PTK)-mediated signal. 4) The PTK-mediated signal was involved in the cAMP-stimulated Na+ transport in rat FDLE cells.

Keywords: cAMP, Tyrosine Phosphorylation, Protein Kinase A, Protein Tyrosine Kinase, Alveolar Epithelium

TOOLS
Similar articles