Journal List > J Korean Med Sci > v.15(Suppl) > 1019178

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Naruse, Suzuki, Ishiguro, Kitagawa, Ko, Yoshikawa, Yamamoto, Hamada, and Hayakawa: Serotonin and pancreatic duct function
Original Article
Journal of Korean Medical Science

Journal of Korean Medical Science 2000; 15(Suppl): S27-S28.

Published online: 25 June 2009

DOI: https://doi.org/10.3346/jkms.2000.15.S.S27

Serotonin and pancreatic duct function

Satoru Naruse, Atsushi Suzuki, Hiroshi Ishiguro, Motoji Kitagawa, Shigeru BH Ko, Toshiyuki Yoshikawa, Akiko Yamamoto, Hiroyuki Hamada, Tetsuo Hayakawa

Internal Medicine II, Nagoya University School of Medicine, Japan.

snaruse@med.nagoya-u.ac.jp

Copyright © 2000 The Korean Academy of Medical Sciences

Abstract

1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.

Keywords: Pancreatic Duct, Serotonin (5-HT), Fluid Secretion, Secretin, Acethylcholine

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