Abstract
Cyclin D1 and cyclin E are the mammalian G1 cydins that are both required and
rate limiting for entry into S phase. Alterations in cell cycle regulators and
subsequent deregulation of the cell cycle are frequently involved in
tumorigenesis and/or tumor progression. We investigated the expression of cyclin
D1 and cyclin E protein in 84 gastric carcinoma by immunohistochemical staining
and also the relevance of each cyclin expression to the clinical outcomes.
Overexpression of cyclin D1 and cyclin E was noted in 21 of 84 (25.0%) and 34 of
84 (40.5%) gastric cancer tissues, respectively. There was a significant
correlation between overexpression of cyclin E and lymph node metastasis
(p=0.003), recurrence (p=0.043), disease free survival (p=0.0378) and overall
survival (p=0.0319), but no correlation was noted between overexpression of
cyclin D1 and other clinicopathologic variables. These findings suggest that
overexpression of cyclin E and cyclin D1 is a frequent finding in gastric cancer
and immunohistochemical analysis for cell cycle regulators, especially cyclin E
might be a useful prognostic indicator in gastric cancer.