Abstract
In order to obtain proton magnetic resonance spectra from the renal tumor in
human kidney we performed localized magnetic resonance spectroscopy using a
saddle-type flexible surface coil. Five patients biopsy-proven as renal cell
carcinoma at different stages were put in supine/lateral position to minimize
motion artifacts while acquiring the spectrum. Water-suppressed 1H spectra were
obtained with localized stimulated echo acquisition mode (STEAM) (20/13.7/2200;
TE/TM/TR) and point resolved spectroscopy (PRESS) (288/2200; TE/TR) sequences.
The principal resonances in the tumor STEAM spectrum were sorbitol (3.85 ppm),
trimethylamines (TMA) (3.25 ppm), two unidentified signals (2.8 and 2.2 ppm),
and lipid (0.9-1.8 ppm). In the PRESS spectrum using a long echo time (288 ms),
two well localized signals, TMA at 3.25 ppm and lactate at 1.35 ppm were
observed from a patient with a tumor at advanced stage. Interestingly only TMA
at 3.25 ppm was observed from the patient with a low grade tumor. The spectral
patterns of the tumor patients were different from those of normal kidney.