Ergonovine stress echocardiography might be a feasible, accurate and safe procedure for the noninvasive diagnosis of coronary vasospasm. During ergonovine stress echocardiography, reversal of spasm is usually achieved by administration of nitroglycerin or nifedipine. However, we experienced a 61 year-old male case of cardiac arrest caused by multiple spasms and refractory of these medications during ergonovine stress echocardiography.