The Short-term Efficacy and Safety of On-line Hemodiafiltration

Hyung-Chul Lee; Joon-Suk Choi; Dae-Hun Lim; Ji-Min Jeong; Pyung-Kyun Park; An-Doc Jung; Myong-Yun Nah; Nam-ho Kim

doi:10.4068/cmj.2010.46.1.44

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Lee, Choi, Lim, Jeong, Park, Jung, Nah, and Kim: The Short-term Efficacy and Safety of On-line Hemodiafiltration

Original Article

Chonnam Medical Journal

Chonnam Medical Journal 2010; 46(1): 44-48.

Published online: 15 April 2010

DOI: https://doi.org/10.4068/cmj.2010.46.1.44

The Short-term Efficacy and Safety of On-line Hemodiafiltration

Hyung-Chul Lee, Joon-Suk Choi, Dae-Hun Lim, Ji-Min Jeong, Pyung-Kyun Park, An-Doc Jung, Myong-Yun Nah, Nam-ho Kim

Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.

Corresponding author (nhk111@chonnam.ac.kr)

Received 9 January 2010 Accepted 4 February 2010

Abstract

Online hemodiafiltration (online HDF) is a new hemodialysis technique that is capable of purifying not only small but also medium- to large-sized molecules. This study aimed to prove the short-term efficacy and safety of online HDF. Between January 2008 and January 2009, a total of 23 patients (56±13 years, male 56.5%) on high-flux hemodialysis (HF-HD) for at least 3 months were switched to online HDF in the predilution mode. Before and after the patients were switched to online HDF, we checked the frequency of hypotension during hemodialysis, subjective symptoms, and a biochemical marker [beta 2-microglobulin (β₂-MG)]. There was no increase in the frequency of hypotension during online HDF. No patients in either group developed a fever or were hospitalized. There were improvements in subjective symptoms including fatigue, clamp, and headache, whereas there was no significant change in laboratory findings (hemoglobin, hematocrit, protein, albumin, Ca, P, K, parathyroid hormone, and β₂-MG). Online HDF revealed no significant changes in dialysis adequacy (Kt/V: 1.68±0.28 in HF-HD vs. 1.63±0.44 in online HDF). In conclusion, online HDF improved subjective symptoms and was safe and adequate, but there was no improvement in laboratory findings.

Keywords: Hemodiafiltration, Beta 2-microglobulin, Safety

Figures and Tables

Table 1

Baseline characteristics

Table 2

Subjective symptoms before and after on-line hemodiafiltation

HF-HD, High flux hemodialysis; On-line HDF, On-line hemodiafiltration.

Table 3

Biochemical changes before and after on-line hemodiafiltation

HF-HD, High flux hemodialysis; β₂-MG, beta-2 microglubulin; On-line HDF, On-line hemodiafiltration; Hgb, hemogrobin; Hct, hematocrit; PTH, parathyroid hormone.

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