Factors Related to Medication Adherence in Outpatients with Schizophrenia under More Than 5 Years of Treatment

Hong Kyu Ihm; Sang Hoon Kim; Jung Ho Kim; Kang Su Ha; Hyun Park

doi:10.4306/jknpa.2016.55.4.397

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Ihm, Kim, Kim, Ha, and Park: Factors Related to Medication Adherence in Outpatients with Schizophrenia under More Than 5 Years of Treatment

Original Article

Journal of Korean Neuropsychiatric Association 2016; 55(4): 397-406.

Published online: 30 November 2016

DOI: https://doi.org/10.4306/jknpa.2016.55.4.397

Factors Related to Medication Adherence in Outpatients with Schizophrenia under More Than 5 Years of Treatment

Hong Kyu Ihm, MD¹, Sang Hoon Kim, MD, PhD^1,², Jung Ho Kim, MA¹, Kang Su Ha, MD³, Hyun Park, PhD³

¹Department of Psychiatry, Chosun University Hospital, Gwangju, Korea.

²Department of Psychiatry, College of Medicine, Chosun University, Gwangju, Korea.

³Department of Medicine, Graduate School, Chosun University, Gwangju, Korea.

Address for correspondence: Sang Hoon Kim, MD, PhD. Department of Psychiatry, College of Medicine, Chosun University, 365 Pilmun-daero, Dong-gu, Gwangju 61453, Korea. Tel +82-62-220-3105, Fax +82-62-225-3659, shckim@chosun.ac.kr

Received 10 October 2016 Revised 20 October 2016 Accepted 25 October 2016

Abstract

Objectives

This study aimed to investigate the medication adherence rate and related factors in chronic schizophrenia.

Methods

A total of 65 (34 male and 31 female) outpatients with schizophrenia and with less than 5 years schizophrenia treatment were randomly selected to participate in the study survey. Medication adherence rate was evaluated by counting remaining tablets. The Korean version of Drug Attitude Inventory-10 (KDAI-10) was used to determine the subjective adherence rate. Adherence was defined as a patient taking more than 80% of their total prescribed medication. Positive KDAI-10 scores indicate good adherence.

Results

The rate of good adherence was 87.7%. Our analysis showed that an older age (r=0.323, p=0.009), longer duration of illness (r=0.296, p=0.017), employment (F=4.41, p=0.016), remaining married (F=5.26, p=0.008), and being supported by family members, especially spouse or siblings (F=3.02, p=0.025) were significantly associated with good adherence. Presence of symptoms such as delusion (p=0.033) and hallucination (p=0.032) were related to poor adherence.

Conclusion

The results indicate that future study should investigate patient characteristics associated with medication adherence and analyze the clinician/patient alliance and its affect on adherence. The results also show that further studies might be useful in developing and validating measures of adherence, as well as in designing and evaluating interventions to improve adherent behaviors.

Keywords: Chronic schizophrenia, Medication adherence, Related factors

Figures and Tables

Table 1

General characteristics of subjects

SD : Standard deviation, DAI : Drug Attitude Inventory, BCIS : Beck Cognitive Insight Scale

Table 2

Socio-demographic and clinical variables related to adherence (categorical variables)

SD : Standard deviation

Table 3

Socio-demographic and clinical variables related to adherence (continuous variables)

R : Pearson's correlation coefficient, DAI : Drug Attitude Inventory, BCIS : Beck Cognitive Insight Scale

Table 4

Multiple regression analysis with K-DAI score as dependent variable and influential factors as predictors (n=65)

K-DAI : Korean version of Drug Attitude Inventory

Acknowledgments

This study was supported by research funds from Chosun University Hospital 2015.

Notes

^{Conflicts of Interest} The authors have no financial conflicts of interest.

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