The Drug Adherence and Treatment Effect of the Paliperidone Long Acting Injection

Harin Kim; Jungsun Lee; Changyoon Kim; Yeonho Joo

doi:10.4306/jknpa.2015.54.1.69

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Kim, Lee, Kim, and Joo: The Drug Adherence and Treatment Effect of the Paliperidone Long Acting Injection

Original Article

Journal of Korean Neuropsychiatric Association 2015; 54(1): 69-75.

Published online: 28 February 2015

DOI: https://doi.org/10.4306/jknpa.2015.54.1.69

The Drug Adherence and Treatment Effect of the Paliperidone Long Acting Injection

Harin Kim, MD, Jungsun Lee, MD, PhD, Changyoon Kim, MD, PhD, Yeonho Joo, MD, PhD

Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Address for correspondence: Jungsun Lee, MD, PhD. Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea. Tel +82-2-3010-3422, Fax +82-2-485-8381, ljssmh@gmail.com

Received 31 October 2014 Revised 9 November 2014 Accepted 26 December 2014

Abstract

Objectives

The aim of this study was to examine the drug adherence and treatment effect of the paliperidone long acting injection (LAI) in patients with schizophrenia or other psychotic disorders.

Methods

We reviewed the medical charts of patients who were prescribed paliperidone LAI from January 2010 to April 2014. Date of each injection, last observation, and first admission after use of the drug were obtained. Kaplan-Meier survival analysis was used for calculation of drug adherence. The dose of paliperidone LAI, concurrent oral antipsychotics, and anticholinergic agent was also obtained. Antipsychotics dose was calculated as olanzapine equivalent dose.

Results

The drug adherence of the paliperidone LAI on day 365 was 65%. The reasons for all cause discontinuation were follow-up loss, no effect, poor insight, rejection, extrapyramidal symptom, pain, etc. A total dose of 9.1 mg of oral antipsychotics was decreased, while the dose of anticholinergic agent was increased.

Conclusion

The drug adherence of the paliperidone LAI was 65%, which was concordant with previous studies. The dose of concurrent oral antipsychotics was increased, while the dose of anticholinergic agent was decreased.

Keywords: Schizophrenia, Paliperidone palmitate, Long acting injection, Medication adherence, Treatment outcome

Figures and Tables

Fig. 1

The Kaplan-Meier survival analysis showing drug adherence of the paliperidone long acting injection.

Fig. 2

The change of concurrent oral antipsychotics use calculated as daily olanzapine equivalent dose. * : Baseline refers to one month period before the first prescription of paliperidone long acting injection.

Table 1

Demographic characteristics of patients

^* : All the patients including those who were lost during observation period, ^† : The patients who were not lost during observation period. SD : Standard deviation

Notes

The authors have no financial conflicts of interest.

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