A Case of Clozapine-Induced Anemia and Thrombocytosis

So Yeon Jeon; Hanson Park

doi:10.4306/jknpa.2015.54.2.252

Journal List > J Korean Neuropsychiatr Assoc > v.54(2) > 1017738

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Jeon and Park: A Case of Clozapine-Induced Anemia and Thrombocytosis

Case Report

Journal of Korean Neuropsychiatric Association 2015; 54(2): 252-256.

Published online: 31 May 2015

DOI: https://doi.org/10.4306/jknpa.2015.54.2.252

A Case of Clozapine-Induced Anemia and Thrombocytosis

So Yeon Jeon, MD^1,², Hanson Park, MD^2,³

¹Department of Psychiatry, Seoul National University Hospital, Seoul, Korea.

²Department of Psychiatry, St. Andrews Neuropsychiatric Hospital, Icheon, Korea.

³Department of Anthropology, College of Social Science, Seoul National University, Seoul, Korea.

Address for correspondence: Hanson Park, MD. Department of Anthropology, College of Social Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea. Tel +82-2-880-6418, Fax +82-2-878-8621, hansonpark@snu.ac.kr

Received 18 February 2015 Revised 22 March 2015 Accepted 8 April 2015

Abstract

Clozapine is a well-known antipsychotic which causes hematologic adverse effects, specifically neutropenia and agranulocytosis (1-3% of patients). However, reports on blood dyscrasias like anemia and thrombocytosis after clozapine treatment are extremely rare. In some cases re-challenge of clozapine could lead to hematopoietic abnormality related to thrombocytopenia or thrombocytosis, which may be a result of an immune reaction. This case report suggests that clinicians should monitor platelet count after re-treatment with clozapine.

Keywords: Clozapine, Anemia, Thrombocytosis, Blood dyscrasia

Figures and Tables

Fig. 1

Hematologic changes during the clozapine re-challenge period.

Notes

^{Conflicts of Interest} The authors have no financial conflicts of interest.

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