Journal List > J Korean Neuropsychiatr Assoc > v.53(6) > 1017702

Oh, Lee, Ryu, Noh, Park, Choi, Kim, and Hong: Intra-Individual Neuropsychological Test Variability : A Comparison of Patients with Schizophrenia, Their Siblings, and Healthy Controls

Abstract

Objectives

Intra-individual variability of cognitive performance across different tests or domains has been reported as an important index of cognitive function. The aim of the current study is to examine the intra-individual variability across different cognitive domains and tests in patients with schizophrenia, their unaffected siblings, and normal controls. We also compared the variability among three patient sub-groups divided according to the duration of illness.

Methods

Comprehensive neurocognitive tests were administered in order to stabilize patients with schizophrenia (n=129), healthy siblings (n=38) of the patients, and normal controls (n=110). Intra-individual variability was computed from the variance of the scores of six cognitive domains of the Measurement and Treatment Research to Improve Cognition in Schizophrenia consensus battery. We examined intra-individual variability across six factor-based cognitive scores and individual test scores of each cognitive domain.

Results

Compared to the normal control and sibling groups, patients showed significantly increased intra-individual variability across six cognitive domains and individual cognitive tests of each domain. Compared to the normal control, siblings showed significantly increased intra-individual variability only across individual tests of the processing of speed domain. Among patient sub-groups, those with the longest duration of illness (≥11 years) showed significantly higher intra- individual variability across six cognitive domains and across individual tests of the processing of speed domain compared to the other two groups.

Conclusion

This study identified cognitive dissonances across six cognitive domain schizophrenia patients. These cognitive characteristics were not observed in the sibling groups and seemed to progress during the course of illness.

Figures and Tables

Table 1
Cognitive domains and tests used
jkna-53-379-i001

*: The Korean version of the Wechsler Adult Intelligence Scale (K-WAIS),34) : The Trail Making Test materials and guidelines used in this study art parts of Korean version of the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological assessment battery,35) : The Korean version of Controlled Oral Word Association Test including the categories of "animal" and "supermarket list" and the letters of three Korean consonant alphabets,36) §: Working Memory Task V1.06, : Korean version of the Rey-Auditory Verbal Learning Test,37) : Korean version of the Rey Complex Figure Test,37) **: Degraded Stimulus-Continuous Performance Test (DS-CPT; UCLA CPT version 8.12),38) ††: Span of apprehension39)

Table 2
Demographic and clinical characteristic of the participants
jkna-53-379-i002

Patients were assigned into three duration of illness-derived groups, A : ≤5 years, B : ≥6 years and ≤10 years, C : ≥11 years. Comparison of sex, age, and education years : among patients total, siblings, and controls. Comparison of age of onset, number of hospitalization, and CGI score : among patients sub-groups (A : B : C). *: Chi-square test, : Kruskal-Wallis test, : Post-hoc test : patients>siblings, healthy controls, §: Post-hoc test : patients<siblings<healthy controls, : Post-hoc test : A, B<C. CGI : Clinical Global Impression

Table 3
Comparison of neuropsychological tests scores and intra-individual variability among patient, sibling, and control groups
jkna-53-379-i003

1=patients, 2=siblings, 3=controls. Analysis of covariance was done using age and education as covariates. *: p<0.05

Table 4
Comparison of neuropsychological tests scores and intra-individual variability among three patients groups divided according to the duration of illness
jkna-53-379-i004

Patients were assigned into three duration of illness-derived groups, A : ≤5 years, B : ≥6 years and ≤10 years, C : ≥11 years. *: p<0.05

Notes

The authors have no financial conflicts of interest.

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