Journal List > J Korean Neuropsychiatr Assoc > v.52(6) > 1017657

Park, Cho, Lee, Joo, and Kim: The Development of Questionnaire for Relapse Assessment in Psychotic Disorder

Abstract

Objectives

The aims of this study were to develop an instrument for detection of relapse in psychotic disorder and to validate the instrument.

Methods

A total of 55 outpatients with psychotic disorder (schizophrenia, schizoaffective disorder, bipolar disorder) and 46 of their caregivers were enrolled. We developed the Questionnaire for Relapse Assessment in Psychotic disorder (QRAP), a self/report inventory. The patients and caregivers drew up the QRAP at two different time points, 'current' and 'the best state during the past three months'. In addition, we rated other established scales in order to evaluate psychotic and mood symptoms of patients. We divided patients into two groups, stable (n=30) and impending relapse (n=35) and evaluated the effectiveness of QRAP by calculating sensitivity and specificity.

Results

For all patients and caregivers, QRAP total score at 'current' was higher than 'the best state during the past three months' and showed significant positive correlation with other established scales. As expected, QRAP total score at 'current' in the impending relapse group was higher than that of the stable group. With cut off criteria 1, the QRAP demonstrated 80.0% sensitivity and 56.3% specificity in caregivers and effectively detected impending relapse.

Conclusion

The results of our study suggest the effectiveness of QRAP as an instrument for detection of relapse in patients with psychotic disorder.

Figures and Tables

Fig. 1
Changes in Questionnaire for Relapse Assessment in Psychotic disorder (QRAP) total scores between stable group and impending relapse group [(A) by patients and (B) by caregivers]. Baseline means the best state during past 3 months.
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Table 1
Demographic and clinical characteristics of stable group and impending relapse group
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* : Using Mann-Whitney U-test. CGI-S : Clinical Global Impression-Severity, HAMD-17 : Hamilton Rating Scale for Depression-17, PANSS : Positive and Negative Syndrome Scale, SD : Standard deviation, YMRS : Young Mania Rating Scale

Table 2
Comparisons of sensitivity and specificity between schizophrenia patients and bipolar disorder patients
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Criteria 1 : ≥3 on change in total scores between 'current' and 'the best state during past 3 months'. Criteria 2 : one of the following ; 1) ≥3 on change in total scores between 'current' and 'the best state during past 3 months' and (≥3 on the number of scored 2, ≥2 on the number of scored 3, or ≥1 on the number of scored 4), 2) ≥3 on change in total scores between 'current' and 'the best state during past 3 months' and (≥2 on the number of scored 3 on item No. 10-14), 3) ≥ score 2 on the item No. 15

Table 3
Correlation analysis between Questionnaire for Relapse Assessment in Psychotic disorder (QRAP) and other established scales with diagnosis
jkna-52-417-i003

BD : Bipolar disorder, CGI-S : Clinical Global Impression-Severity, HAMD-17 : Hamilton Rating Scale for Depression-17, PANSS : Positive and Negative Syndrome Scale, SPR : Schizophrenia, YMRS : Young Mania Rating Scale

Notes

The authors have no financial conflicts of interest.

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