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Hwang, Min, Kwon, Cheon, Park, Chai, and Kim: Neurocognitive Function Impairment in Alcohol Dependent Patients with Diabetes Mellitus
Original Article
Journal of Korean Neuropsychiatric Association

Journal of Korean Neuropsychiatric Association 2012; 51(5): 285-290.

Published online: 30 September 2012

DOI: https://doi.org/10.4306/jknpa.2012.51.5.285

Neurocognitive Function Impairment in Alcohol Dependent Patients with Diabetes Mellitus

Hye-Rim Hwang, MD1, Jung-Ah Min, MD1, Min Kwon, MS2, Young-Hoon Cheon, MD3, Jae-Woo Park, MA4, Sook-Hee Chai, PhD5, Dai-Jin Kim, MD, PhD1, 2

1Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.

2Addiction Clinic, Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

3Department of Psychiatry, Incheon Chamsarang Hospital, Incheon, Korea.

4Department of Psychology, The Catholic University of Korea College of Social Science, Bucheon, Korea.

5Department of Addiction Rehabilitation with Social Welfare, Eulji University of Korea, Seongnam, Korea.

Address for correspondence: Dai-Jin Kim, MD, PhD. Department of Psychiatry, The Catholic University of Korea College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Korea. Tel +82-2-2258-6086, Fax +82-2-594-3870, kdj922@catholic.ac.kr

Received 18 June 2012       Revised 2 July 2012       Accepted 18 July 2012

Copyright © 2012 Korean Neuropsychiatric Association

Abstract

Objectives

Diabetes and alcohol dependence are considered as independent risk factors for cognitive impairment. This research was to investigate whether cognitive functions in diabetic alcohol dependent patients were more impaired than non-diabetic alcohol dependent patients.

Methods

A cross-sectional study was conducted in alcohol dependence patients (n=138). Patients with alcohol dependence diagnosed by Diagnostic and Statistical Manual of Mental Disorder, 4th edition, Text Revision underwent a 75 g oral glucose tolerance test, to classify to diabetics group and non-diabetics group. In addition to demographic and clinical characteristics, cognitive functions assessed using the Korean-Mini Mental Status Examination (K-MMSE), word list memory test, and word fluency test, word list recall test from Korean version of the consortium to establish a registry for Alzheimer's disease, and block design test, digit span test, and digit symbol test from Korean-Wechsler Adult Intellogence Scale were compared between the two groups.

Results

There was no significant difference in demographic and other clinical characteristics between the non-diabetic and diabetic alcoholic patients. Compared to non-diabetic alcoholic patients, diabetic alcoholic patients were more impaired on language of K-MMSE (p=0.028) and digit symbol test (p=0.044).

Conclusion

These findings suggest the more severe impairment of selective cognitive functions in diabetic alcoholic patients than non-diabetic alcoholic patients. Future replication of these findings in a large population is necessary.

Keywords: Alcohol dependence, Diabetes, Comorbidity, Cognition

Figures and Tables

Table 1
Demographic and clinical characteristics of nondiabetic- and diabetic-alcoholic patients
jkna-51-285-i001

Data are mean±SD. BMI : Body index mass, ADS : Alcohol Dependence Scale, VAS : Visual Analogue Scale, BDI : Beck Depression Inventory, BAI : Beck Anxiety Inventory, SD : Standardard deviation

Table 2
Comparison of neuropsychological test results between diabetic alcohol dependent patients and non-diabetic alcohol dependent patients
jkna-51-285-i002

K-MMSE : Korean-Mini Mental Status Examination, CERAD-K : Korean version of the consortium to establish a registry for Alzheimer's disease, K-WAIS : Korean-Wechsler Adult Intelligence Scale

Notes

The authors have no financial conflicts of interest.

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