Journal List > Korean Circ J > v.47(3) > 1017478

Gwon, Jeon, Kang, Jang, Park, Shin, Moon, Kim, Kim, Bae, Hur, Kim, Choi, Han, and Kim: The Practice Pattern of Percutaneous Coronary Intervention in Korea: Based on Year 2014 Cohort of Korean Percutaneous Coronary Intervention (K-PCI) Registry

Abstract

Background and Objectives

Appropriate use criteria (AUC) was developed to improve the quality of percutaneous coronary intervention (PCI). However, these criteria should consider the current practice pattern in the country where they are being applied.

Materials and Methods

The algorithm for the Korean PCI practice pattern (KP3) was developed by modifying the United States-derived AUC in expert consensus meetings. KP3 class A was defined as any strategy with evidence from randomized trials that was more conservative for PCI than medical therapy or coronary artery bypass graft (CABG). Class C was defined as any strategy with less evidence from randomized trials and more aggressive for PCI than medical therapy or CABG. Class B was defined as a strategy that was partly class A and partly class C. We applied the KP3 classification system to the Korean PCI registry.

Results

The KP3 class A was noted in 67.7% of patients, class B in 28.8%, and class C in 3.5%. The median proportion of class C cases per center was 2.0%. The distribution of KP3 classes varied significantly depending on clinical and angiographic characteristics. The proportion of KP3 class C cases per center was not significantly dependent on PCI volume, but rather on the percentage of ACS cases in each center.

Conclusion

We report the current PCI practice pattern by applying the new KP3 classification in a nationwide PCI registry. The results should be interpreted carefully with due regard for the complex relationships between the determining variables and the healthcare system in Korea.

Introduction

Appropriate use criteria (AUC) were developed to monitor the use and improve the quality of percutaneous coronary intervention (PCI) in the United States in 2009,1) and updated in 20122) and 2016.3) Since the first publication of AUC for coronary revascularization, there have been significant reductions in the proportion of PCI classified as inappropriate.4) However, these criteria are difficult to apply to Korean practice considering differences in the practice environment and healthcare system in the country.5)
Once developed, the AUC need to be tested in a nationwide database. The CathPCI registry was a founding member of the National Cardiovascular Data Registry (NCDR), which represents one of the most important efforts to monitor the quality of PCI practice since 1997.6) The utility of the CathPCI registry lies in its comprehensive scope, encompassing treatment monitoring, quality improvement, clinical research, and support for guideline developments. The Korea PCI (K-PCI) registry is the first nationwide PCI registry in Korea for the same purpose.
In this study, we developed Korean AUC reflecting the current Korean practice pattern and tested them in a nationwide database. We hope that this Korean AUC will be utilized for development of improved tools for PCI quality monitoring. Thus, the purpose of this study was to develop criteria for the Korean PCI practice pattern (KP3) and to analyze the K-PCI registry based on the developed criteria.

Materials and Methods

Study population and variables

The K-PCI registry is a retrospective multicenter registry of patients with coronary artery disease who underwent PCI. From January 2014 through December 2014, all consecutive patients were enrolled from 92 high volume coronary intervention centers in Korea.
This was an all-comer study with no exclusion criteria. The local Institutional Review Board at each center approved this study. Informed consent was waived at all centers, considering the study's retrospective enrollment without clinical follow-up design. Data were collected using a web-based reporting system.
This study was directed by the Korean PCI Registry Committee (co-directed by Dr. Hyo-Soo Kim and Dr. Hyeon-Cheol Gwon), and co-sponsored by the Korean Society of Cardiology and the Korean Society of Interventional Cardiology.

Development of the algorithm for Korean PCI practice pattern and study endpoint

The Korean PCI practice pattern (KP3) algorithm was determined in consensus meetings attended by members of the Korean PCI Registry Committee. The key algorithm was adopted from the ‘AUC for coronary revascularization developed by ACCF/SCAI/STS/AATS/AHA/ASNC/HFSA/SCCT’2, which was modified with consideration for the Korean healthcare system and environment (Supplementary Data in the online-only Data Supplement).
First, for cases of acute coronary syndrome (ACS) defined as unstable angina or myocardial infarction, we developed possible indications for PCI using six clinical components of patients presenting with ACS: [1] clinical presentation (e.g., STEMI, NSTEMI, unstable angina), [2] evidence of cardiogenic shock upon arrival, [3] administration of fibrinolytic therapy, [4] evidence of heart failure, persistent or recurrent ischemia, hemodynamic instability, or unstable ventricular arrhythmia, [5] time of initial presentation (≤12 hours vs. >12 hours), and [6] high risk features associated with NSTEMI or unstable angina. As a result, we developed 9 indications for PCI in ACS treatment. We then rated each indication as KP3 class A, B, or C. KP3 class A was defined as the strategy evidenced by many randomized trials and/or more conservative for PCI rather than medical therapy or coronary artery bypass surgery. KP3 class C was defined as the strategy less evidenced by randomized trials and/or more aggressive for PCI compared to medical therapy or coronary artery bypass surgery. Class B was partly class A and partly class C with conflicting evidence and/or a divergence of opinions among the committee members.
Second, for cases of stable non-ACS, we developed possible indications for PCI using five clinical components of stable CAD patients: [1] severity of ischemic symptoms (asymptomatic, Canadian Cardiovascular Society [CCS] Class I or II vs. III or IV), [2] extent of anti-ischemic medical therapy (none vs. one or more classes of anti-anginal therapy), [3] results of noninvasive or invasive supportive tests including IVUS and FFR (not done/negative test: low-risk findings vs. positive test: high-risk findings), [4] prior history of bypass surgery, and [5] extent of coronary disease (1-, 2-, 3-vessel disease, with or without proximal LAD, CTO, or left main stenosis). As a result, we developed 38 indications for PCI in the treatment of non-ACS patients (Supplementary Data in the online-only Data Supplement). We then rated each indication for PCI for non-ACS patients as KP3 class A, B, or C depending on the presence and severity of angina-related symptoms. Angina-related symptoms were defined according to CCS classification.
The KP3 algorithm was designed to describe nationwide PCI practice patterns for cases involving the preferential use of PCI over medical treatment or coronary artery bypass graft (CABG), but was not designed to examine the suitability of individual PCI cases.

Statistical analysis

Statistical analysis was performed independently in collaboration with Duke University, USA. Continuous variables are presented as medians with interquartile ranges (IQRs), and categorical variables are presented as numbers (percentages). Continuous variables were compared using Student's t-test or the Wilcoxon rank-sum test. Categorical data were evaluated using the Chi-square test. All p values were two-tailed. A p value<0.05 was considered statistically significant.

Results

Study population

From January 2014 through December 2014, 44967 consecutive patients were enrolled from 92 high volume coronary intervention centers out of a total 150 intervention centers currently operating in Korea. Three of 92 centers failed to submit all patients in the registry.

Baseline clinical and procedural characteristics

Baseline clinical and angiographic characteristics, procedural details, and in-center outcomes will be reported in a separate paper in the Korean Circulation Journal. Briefly, the proportion of male patients was 70.3%, and the median age of all patients was 66.0 (IQR 57.0-74.0) years. Diabetes was found in 35.9% of patients, renal failure in 6.4%, prior myocardial infarction in 9.2%, prior PCI in 24.0%, prior CABG in 1.3%, prior cerebrovascular disease in 8.8%, and peripheral artery disease in 2.7%. The distribution of clinical diagnoses was as follows: silent ischemia 3.5%, stable angina 22.6%, unstable angina 35.9%, non-ST elevation myocardial infarction 19.7%, and ST-elevation myocardial infarction 18.4%. Cardiogenic shock was noted in 3.1% of patients and cardiac arrest in 2.3% of patients. A noninvasive test before PCI (including treadmill test, thallium SPECT, stress echocardiography, and stress magnetic resonance imaging) was performed in 13.9% of patients (9.8% in ACS patients and 25.8% in non-ACS patients). Multivessel disease was noted in 66.3%, left main disease in 4.9%, and proximal LAD lesion in 31.9% of patients. PCI was performed electively in 66.7% of patients, and was otherwise performed as an urgent or emergent procedure. A drug-eluting stent was used in 91.3% of patients, a bare metal stent in 1.1%, and balloon angioplasty in all other cases.

Distribution of classes of Korean PCI practice pattern

Korean PCI practice pattern (KP3) class A was noted in 67.7%, class B in 28.8%, and class C in 3.5% of cases (Table 1, Fig. 1). The distributions of KP3 classes were significantly different according to demographic, clinical, and angiographic variables (Table 1, Fig. 1). Notably, class A was found more frequently in patients with ACS, while class C was more common in non-ACS patients (p<0.001), noted in 13.5% of the patients. Class C was noted in 29.7% of asymptomatic patients, in 10.9% of patients with mild chest pain (CCS class I or II), and in 0% of patients with severe chest pain (CCS class III or IV). Regarding angiographic characteristics, class C was noted in a small proportion of patients with complex coronary artery diseases such as left main disease, multi-vessel disease, or chronic total occlusion.

Proportion of class C patients in the centers

The median proportion of class C cases in all centers was 2.0% (interquartile range 0.5-5.2%) (Fig. 2). A greater than 15% proportion of class C cases was noted only in two centers, while a proportion less than 1% was noted in 29 centers. The proportion of class C cases found in the hospital setting was less variable in Seoul and Gyeonggi province (which is the nearest province to Seoul) (Fig. 2B). The proportion of class C cases was not dependent on the number of PCIs performed per center (r=-0.06, p=0.601, Fig. 3A). The initial diagnosis of ACS was significantly associated with the proportion of class C cases found in a given center (r=-0.65, p<0.001, Fig. 3B).

In-hospital clinical outcomes according to KP3 class

In-hospital clinical outcomes were similar among the three KP3 classes in non-ACS patients, whereas they were significantly different in ACS patients (Table 2). However, there were no signs of worse in-hospital outcomes in class C patients.

Discussion

The aim of this study was to develop the Korean PCI practice pattern (KPPP, KP3) and apply it to a nationwide database of PCI cases. The key findings were as follows: 1) KP3 class A was noted in 67.7% of patients, class B in 28.8%, and class C in 3.5%, 2) the median proportion of class C was 2.0% of patients (IQR 0.5-5.2%), and 3) the distribution of KP3 classes varied significantly depending on clinical, angiographic, and procedural characteristics. KP3 class was mainly determined by the severity of angina-related symptoms and the diagnosis of ACS. For example, the same procedure would be categorized as class A in the case of symptomatic ACS, while it would be categorized as class C in the case of less symptomatic, stable CAD. 4) The proportion of KP3 class C cases in each intervention center was not dependent on PCI volume, but on the proportion of ACS cases.
American guidelines recommend the participation of interventional centers in a regional or national PCI registry for the purpose of benchmarking outcomes against current national norms. The CathPCI registry has been developed as a nationwide registry by the American College of Cardiology in the United States as previously described.7) Sweden and other European countries have also developed nationwide registries of PCI, established either by academic societies or the government.8)9) The Korea percutaneous coronary intervention (K-PCI) registry is the first nationwide PCI registry in Korea, established as a joint effort of the Korean Society of Cardiology and the Korean Society of Interventional Cardiology.
Appropriate use criteria (AUC) were developed based on the CathPCI registry, which was built to document cases involving PCI. However, it is challenging to apply these criteria to Korean practice considering the different practice environment in Korea, as well as the different database structure of the K-PCI registry. When the AUC were applied in Japan, the differences between the two countries were acknowledged, and local discrepancies of practice were considered.10) In this study, we adopted key algorithms from the ‘AUC for coronary revascularization’ developed by American academic societies2) and revised them to reflect Korean contemporary practice in consensus meetings of the members of the Korean PCI Registry Committee.
The clinical practice environment in Korea is different that of the US or European countries, and this influences the decision for diagnostic study and/or revascularization in real-world practice. For example, medical costs associated with physicians and invasive studies are relatively low in Korea, while those associated with noninvasive studies were relatively high. The use of drug-eluting stents was consistently high in Korea, and Korean real-world data reported excellent safety and short- and long-term outcomes associated with PCI, especially with second-generation drug-eluting stents.11) When considering the applicability of the Korean practice pattern algorithm, the incorporation of results from noninvasive risk stratification, symptoms, medication status, and extent of coronary disease as assessed by angiography was modified (Supplementary Data in the online-only Data Supplement). The purpose of the algorithm of the Korean PCI Practice Pattern was to describe nationwide distributions of PCI practice patterns for cases involving the preferential use of PCI over medical treatment or CABG, and not to examine the suitability of PCI for individual cases. Practice pattern reporting involves the largest, voluntary, nationwide studies in order to properly document the differences and heterogeneity of PCI usage in Korea by Korean medical professional societies. This report should be the basis for efforts to develop Korean standards for the use of PCI. Further studies are needed to fill the gaps in clinical evidence and to improve ischemic heart disease outcomes.
Most patients were categorized as KP3 class A or B, and only 3.5% of patients were categorized as class C. The distribution of the classes was found to be significantly influenced by all of the important clinical and angiographic variables, partly due to the number of cases. A diagnosis of ACS and angina-related symptoms as measured by CCS class seem to be the most influential variables for determining KP3 class. These results contradict prior reports. Although the vast majority of PCI performed in acute settings was classified as appropriate using the standardized AUC from the US NCDR CathPCI registry, approximately 12% of procedures performed in a non-acute setting were classified as inappropriate.12) A total of 221252 non-acute procedures were classified as inappropriate because physicians performed PCI more commonly in men, in Caucasian patients, and in those with private insurance.13) They also found that those admitted to rural hospitals were less likely to undergo inappropriate PCI than those treated at suburban hospitals. In our study, the median proportion of class C cases per center was 2.0%, and this proportion was more than 15% in only two centers. The proportion of class C cases was not correlated with PCI volume, but the distribution of class C cases in each interventional center was highly dependent on the proportion of patients with ACS and severe symptoms.
We think the current general practice pattern abides mostly by the current guidelines and expert consensus. The proportion of classes must have been influenced by the algorithm of KP3 classification system, but these numbers will be reference values for development of future AUC criteria in Korea. Therefore, these results should be interpreted very carefully when applied to a specific center or operator, considering the complex relationships between the variables. Moreover, the in-hospital clinical outcomes were not worse in patients categorized as class C. Long-term outcomes according to KP3 class should be analyzed in future studies. Therefore, the KP3 class system should not be utilized as a guide for reimbursement.14)
It is notable the class C was found mostly in non-ACS patients (patients with silent ischemia and stable angina). Also, noninvasive tests seem to be underutilized in this Korean population. Investigation into the proper utilization of noninvasive tests in non-ACS patients with cost-benefit assessment in the Korean healthcare system is warranted.

Limitations of this study

The K-PCI registry is the largest PCI registry in Korea and includes most patients from the high volume centers in Korea. This study, however, has several limitations. 1) This study did not enroll all patients who underwent PCI in Korea and the results represent only those patients treated in high volume centers in Korea. 2) This study used a retrospective registry rather than a prospective registry. Therefore, definitions of certain variables might vary from center to center, although we provided strict definitions for all variables before patient enrollment. On-site monitoring was conducted in a small number of centers, and not all cases were monitored for the accuracy of reports given to our team of researchers. 3) The algorithm of Korean PCI practice pattern was designed by members of the Korean PCI Registry Committee who modified the AUC used in the United States through expert consensus. The external validity of these criteria has not yet been determined and must be the subject of future analysis.

Conclusion

We report the current PCI practice pattern in Korea using the new Korean PCI practice pattern algorithm through analysis of a nationwide, real-world PCI registry. The results of this study should be interpreted carefully with due regard to the complex relationships between the determining variables and the insurance and healthcare systems in Korea. This study provides background to develop the ‘Korean Appropriate Use Criteria for PCI,’ ultimately aiding in the development of rational guidelines and administrative policies for the use of PCI in Korea.

Acknowledgments

This study was co-sponsored by the Korean Society of Cardiology and the Korean Society of Interventional Cardiology.

Notes

The authors have no financial conflicts of interest.

References

1. Patel MR, Dehmer GJ, Hirshfeld JW, et al. ACCF/SCAI/STS/AATS/AHA/ASNC 2009 appropriateness criteria for coronary revascularization: a report by the American college of cardiology foundation appropriateness criteria task force, society for cardiovascular angiography and interventions, society of thoracic surgeons, American association for thoracic surgery, American heart association, and the American society of nuclear cardiology endorsed by the American society of echocardiography, the heart failure society of America, and the society of cardiovascular computed tomography. J Am Coll Cardiol. 2009; 53:530–553. PMID: 19195618.
2. Patel MR, Dehmer GJ, Hirshfeld JW, et al. ACCF/SCAI/STS/AATS/AHA/ASNC/HFSA/SCCT 2012 appropriate use criteria for coronary revascularization focused update: a report of the American college of cardiology foundation appropriate use criteria task force, society for cardiovascular angiography and interventions, society of thoracic surgeons, American association for thoracic surgery, American heart association, American society of nuclear cardiology, and the society of cardiovascular computed tomography. J Am Coll Cardiol. 2012; 59:857–881. PMID: 22296741.
3. Patel MR, Calhoon JH, Dehmer GJ, et al. ACC/AATS/AHA/ASE/ASNC/SCAI/SCCT/STS 2016 appropriate use criteria for coronary revascularization in patients with ACSs: a report of the American college of cardiology appropriate use criteria task force, American association for thoracic surgery, American heart association, American society of echocardiography, American society of nuclear cardiology, society for cardiovascular angiography and interventions, society of cardiovascular computed tomography, and the society of thoracic surgeons. J Am Coll Cardiol. 2017; 69:570–591. PMID: 28012615.
4. Desai NR, Bradley SM, Parzynski CS, et al. Appropriate use criteria for coronary revascularization and trends in utilization, patient selection, and appropriateness of percutaneous coronary intervention. JAMA. 2015; 314:2045–2053. PMID: 26551163.
5. Committee for the Korean guidelines for the management of dyslipidemia. 2015 Korean guidelines for the management of dyslipidemia: executive summary (English translation). Korean Circ J. 2016; 46:275–306. PMID: 27275165.
6. Wayangankar SA, Bangalore S, McCoy LA, et al. Temporal trends and outcomes of patients undergoing percutaneous coronary interventions for cardiogenic shock in the setting of acute myocardial infarction: a report from the CathPCI Registry. JACC Cardiovasc Interv. 2016; 9:341–351. PMID: 26803418.
7. Brindis RG, Fitzgerald S, Anderson HV, et al. The American college of cardiology-national cardiovascular data registry (ACC-NCDR): building a national clinical data repository. J Am Coll Cardiol. 2001; 37:2240–2245. PMID: 11419906.
8. Jernberg T, Attebring MF, Hambraeus K, Shaw RE, Weintraub WS, Williams JF. The Swedish web-system for enhancement and development of evidence-based care in heart disease evaluated according to recommended therapies (SWEDEHEART). Heart. 2010; 96:1617–1621. PMID: 20801780.
9. García del Blanco B, Hernández Hernández F, Rumoroso Cuevas JR, et al. Spanish cardiac catheterization and coronary intervention registry. 23rd Official report of the Spanish society of cardiology working group on cardiac catheterization and interventional cardiology (1990-2013). Rev Esp Cardiol (Engl Ed). 2014; 67:1013–1023. PMID: 25455754.
10. Inohara T, Kohsaka S, Miyata H, et al. Appropriateness ratings of percutaneous coronary intervention in Japan and its association with the trend of noninvasive testing. JACC Cardiovasc Interv. 2014; 7:1000–1009. PMID: 25234672.
11. Palmerini T, Biondi-Zoccai G, Della Riva D, et al. Stent thrombosis with drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis. Lancet. 2012; 379:1393–1402. PMID: 22445239.
12. Chan PS, Patel MR, Klein LW, et al. Appropriateness of percutaneous coronary intervention. JAMA. 2011; 306:53–61. PMID: 21730241.
13. Chan PS, Rao SV, Bhatt DL, et al. Patient and hospital characteristics associated with inappropriate percutaneous coronary interventions. J Am Coll Cardiol. 2013; 62:2274–2281. PMID: 24055743.
14. Feldman DN, Naidu SS, Duffy PL. Inappropriate use of the appropriate use criteria (AUC) as a guide for reimbursement. J Invasive Cardiol. 2014; 26:559–561. PMID: 25274868.

Supplementary Materials

The online-only Data Supplements are available with article at https://doi.org/10.4070/kcj.2017.0070

Supplementary Table 1

Common variables considered to develop indications
kcj-47-320-s001.pdf

Supplementary Table 2

Patients with acute coronary syndrome
kcj-47-320-s002.pdf

Supplementary Table 3

Patients without prior bypass surgery
kcj-47-320-s003.pdf

Supplementary Table 4

Patients with prior bypass surgery (without acute coronary syndrome)
kcj-47-320-s004.pdf

Supplementary Table 5

Method of revascularization: MVD, CCS III/IV, and/or positive noninvasive testing
kcj-47-320-s005.pdf
Fig. 1

The proportion of class A, B and C cases according to clinical and angiographic variables.

kcj-47-320-g001
Fig. 2

The proportion of class C cases among hospitals. (A) In all hospitals, median proportion was 2.0% (interquartile range 0.5-5.2%), (B) by geographic region.

kcj-47-320-g002
Fig. 3

Determining factors of the proportion of class C in the hospital. (A) Relationship between the proportion of class C cases and the number of PCIs performed in the hospital. (B) Relationship between the proportion of class C cases and the proportion of ACS cases in the hospital. The geographic region of the hospital is indicated as follows; Seoul as an open circle, Gyeonggi province as a gray circle, and other provinces as closed circles. PCI: percutaneous coronary intervention, ACS: acute coronary syndrome.

kcj-47-320-g003
Table 1

Korean PCI practice pattern criteria

kcj-47-320-i001
Class A (n=30426) Class B (n=12963) Class C (n=1578) p
All patients 30426 (67.7) 12963 (28.8) 1578 (3.5)
Gender <0.001
 Men 21800 (69.0) 8716 (27.6) 1074 (3.4)
 Women 8626 (64.5) 4247(31.7) 504 (3.8)
Age group <0.001
 <55 years 6016 (70.4) 2279 (26.7) 246 (2.9)
 55-64 years 8000 (66.7) 3559 (29.7) 434 (3.6)
 65-74 years 8945 (65.9) 4086 (30.1) 538 (4.0)
 ≥75 years 7465 (68.7) 3039 (28.0) 360 (3.3)
ACS <0.001
 No 7726 (65.9) 2415 (20.6) 1578 (13.5)
 Yes 22700 (68.3) 10548 (31.7) 0 (0.0)
Clinical diagnosis <0.001
 Silent ischemia 726 (46.8) 465 (29.9) 362 (23.3)
 Stable angina 7000 (68.9) 1950 (19.2) 1216 (11.9)
 Unstable angina 7345 (45.5) 8782 (54.5) 0 (0.0)
 NSTEMI 7205 (81.5) 1634 (18.5) 0 (0.0)
 STEMI 8150 (98.4) 132 (1.6) 0 (0.0)
Diabetes 0000.024
 No 19561 (67.9) 8273 (28.7) 969 (3.5)
 Yes 10843 (67.2) 4688 (29.0) 608 (3.8)
Renal failure 0000.032
 No 28375 (67.5) 12171 (29.0) 1464 (3.5)
 Yes 2003 (69.6) 768 (26.7) 106 (3.7)
Angina symptoms <0.001
 No symptoms 570 (42.8) 367 (27.5) 395 (29.7)
 CCS class I-II 5265 (69.8) 1454 (19.3) 821 (10.9)
 CCS class III - IV 1172 (90.1) 129 (9.9) 0 (0.0)
Noninvasive test <0.001
 Not done or negative 27167 (67.1) 11752 (29.0) 1578 (3.9)
 Positive 3259 (72.9) 1211 (27.1) 0 (0.0)
Antianginal medications <0.001
 None 14617 (69.4) 5359 (25.4) 1103 (5.2)
 1 8019 (68.1) 3524 (29.9) 238 (2.0)
 2 or more 7790 (64.3) 4080 (33.7) 237 (2.0)
Angiographic characteristics
 Left main disease 3158 (99.1) 27 (0.85) 3 (0.1) <0.001
 Multi-vessel disease 18083 (71.4) 6643 (26.2) 612 (2.4) <0.001
 Three-vessel disease 8505 (79.8) 2159 (20.2) 0 (0.0) <0.001
 Proximal LAD lesion 13501 (71.9) 4817 (25.6) 472 (2.5) <0.001
 Chronic total occlusion 3437 (72.5) 1192 (25.2) 111 (2.3) <0.001
PCI volume of the center <0.001
 Low tertile 3849 (62.7) 1996 (32.5) 292 (4.8)
 Mid tertile 9050 (71.9) 3137 (24.9) 399 (3.2)
 High tertile 17527 (66.8) 7830 (29.8) 887 (3.4)
Geographic region <0.001
 Seoul 16078 (68.6) 6596 (28.2) 749 (3.2)
 Gyeonggi province 5205 (67.7) 2208 (28.7) 270 (3.5)
 Other provinces 913 (66.0) 4158 (30.0) 559 (4.0)

Values are presented as number (%). PCI: percutaneous coronary intervention, CCS: Canadian cardiology society, LAD: left anterior descending artery

Table 2

Clinical outcomes according to KP3 class

kcj-47-320-i002
Class A Class B Class C p
Non-ACS patients
 Death 25 (0.3) 13 (0.5) 7 (0.4) 0.303
 Cardiac death 8 (0.1) 3 (0.1) 4 (0.3) 0.315
 Non-fatal MI 95 (1.2) 7 (0.3) 1 (0.1) <0.001
 Stent thrombosis 4 (0.1) 6 (0.2) 1 (0.1) 0.021
 Stroke 5 (0.1) 4 (0.2) 0 (0) 0.146
 Urgent PCI 6 (0.1) 2 (0.1) 0 (0) 0.534
 Transfusion 83 (1.1) 30 (1.2) 19 (1.2) 0.754
ACS patients
 Death 940 (4.1) 38 (0.4) - <0.001
 Cardiac death 674 (3.0) 15 (0.1) - <0.001
 Non-fatal MI 536 (2.4) 62 (0.6) - <0.001
 Stent thrombosis 144 (0.6) 17 (0.2) - <0.001
 Stroke 66 (0.3) 15 (0.1) - 0.011
 Urgent PCI 89 (0.4) 21 (0.2) - 0.004
 Transfusion 681 (3.0) 165 (1.6) - <0.001

Values are presented as number (%). KP3: Korean PCI practice pattern, MI: myocardial infarction, ACS: acute coronary syndrome, PCI: percutaneous coronary intervention

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