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Kim, Jeoung, Yum, Kim, and Kim: Spontaneous Baroreflex Sensitivity and Multifractal Hurst Analysis of Heart Rate
Original Article
Korean Circulation Journal

Korean Circulation Journal 2007; 37(9): 443-448.

Published online: 30 September 2007

DOI: https://doi.org/10.4070/kcj.2007.37.9.443

Spontaneous Baroreflex Sensitivity and Multifractal Hurst Analysis of Heart Rate

Jin-Soo Kim, MD1, Eun-Young Jeoung, MD1, Myung-Kul Yum, MD1, Nam Su Kim, MD1, Jun-Soo Kim, MD2

1Department of Pediatrics, College of Medicine, Hanyang University, Guri, Korea.

2Department of Cardiac and Vascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Corresponding author (mkyumm@hanyang.ac.kr)

Received 31 March 2007       Revised 10 July 2007       Accepted 31 July 2007

© 2007, The Korean Society of Circulation

Abstract

Background and Objectives

This study was designed to examine whether the multifractal Hurst exponents of heart rate can estimate activating and deactivating spontaneous baroreflex sensitivity (SBRS).

Subjects and Methods

Age and sex matched 24 healthy volunteers were placed in the supine position and head-up tilt position for 30 minutes, and the systolic blood pressure and heart rate were measured in an noninvasive manner. When the RR interval (RRI) sequence and systolic pressure sequence simultaneously increased or decreased for more than three successive beats, the slope of the linear regression line of systolic blood pressure and RR interval sequence was defined as the value of spontaneous baroreflex sensitivity (SBRS). From the RR intervals, very short-term (α range, ≤12 heartbeats), short-term (β range, ≥12 heartbeats), and the multrifractal Hurst exponents were calculated to determine the linear correlation.coefficients for SBRS.

Results

In the supine position, the linear correlation coefficients (p) of SBRS and H-5α, H-4α, H-3α, H-2α, H-1α, H1α, H2α, H3α, H4α, H5α were -0.195 (NS), -0.207 (NS), -0.232 (NS), -0.282 (NS), -0.355 (NS), -0.621 (0.003), -0.650 (0.001), -0.677 (0.001), -0.699 (0.0006) and -0.708 (0.0005), respectively. In the tilting position, the linear correlation coefficients of SBRS and H-5β, H-4β, H-3β, H-2β, H-1β, H1β, H2β, H3β, H4β, H5β were 0.024 (NS), 0.020 (NS), 0.010 (NS), -0.028 (NS), -0.193 (NS), -0.627 (0.0034), -0.607 (0.0045), -0.598 (0.0053), -0.572 (0.0084) and -0.539 (0.0141), respectively.

Conclusion

Some of the very short-term and short-term generalized Hurst exponents, such as H5α and H1β, can be used for the estimation of spontaneous baroreflex sensitivity during patient placement in the supine and head-up tilt position, respectively.

Keywords: Baroreflex, Heart rate, Blood pressure

Figures and Tables

Fig. 1
A and B are two RRI sequences recorded in supine position and head-up tilt position. C and D are systolic blood pressure recorded in supine position and head-up tilt position. RRI: RR interval.
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Fig. 2
Spontaneous baroreflex sensitivity sequence method. SBP: systolic blood pressure.
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Fig. 3
A and B, Multifractal Hurst analyses of the structure function, <Δyτ(t)q>~τq*H(q), of the RRI sequence shown in Fig. 1A and B, respectively. Two linear scaling regions, the very-short-term range (4≤τ≤12 beats) and the short-term range (12≤τ≤90 beats) are indicated. RRI: RR interval.
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Fig. 4
The plot of RR interval against systolic blood pressure. The average of the slopes of the lines is the spontaneous baroreflex sensitivity. Dot line: activating baroreflex sensitivity, Solid line: deactivating baroreflex sensitivity.
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Table 1
Correlation between very short term Hurst exponent and baroreflex sensitivity
kcj-37-443-i001

BRS: baroreflex sensitivity, Hα: very short-term Hurst exponent, Value: linear correlation coefficient, ( ): p

Table 2
Correlation between short term Hurst exponent and baroreflex sensitivity
kcj-37-443-i002

BRS: baroreflex sensitivity, Hβ: short-term Hurst exponent, Value: linear correlation coefficient, ( ): p

Table 3
Very short-term Hurst exponent values
kcj-37-443-i003

Hα: very short-term Hurst exponent

Table 4
Short-term Hurst exponent values
kcj-37-443-i004

Hβ: short-term Hurst exponent

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