Journal List > Korean Circ J > v.36(9) > 1016161

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Hong, Choi, Zhu, Lee, Lim, Chung, Choi, Park, Suh, and Han: Echocardiographic Assessment of Left Ventricular Diastolic Function in Transitional Circulation Period
Original Article
Korean Circulation Journal

Korean Circulation Journal 2006; 36(9): 652-660.

Published online: 30 September 2006

DOI: https://doi.org/10.4070/kcj.2006.36.9.652

Echocardiographic Assessment of Left Ventricular Diastolic Function in Transitional Circulation Period

Joon-Seok Hong, MD4, Jung Yun Choi, MD1, 3, Ling Zhu, MD3, Jung Ha Lee, MD6, In Sook Lim, MD3, Yoon Sook Chung, MD3, Chang Won Choi, MD1, 3, Kyo Hoon Park, MD2, 4, Chang Suk Suh, MD2, 4, Eun Sook Han, RDCS5

1Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea.

2Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.

3Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.

4Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

5Department of Physiologic Diagnostic Laboratory, Seoul National University Bundang Hospital, Seongnam, Korea.

6Department of Pediatrics, College of Medicine, Dongguk University, Ilsan, Korea.

choi3628@snubh.org

Received 16 June 2006       Accepted 28 August 2006

Copyright © 2006 The Korean Society of Circulation

Abstract

Background and Objectives

During the transitional period from fetal to neonatal life, there are dramatic changes in the newborn circulation. Among these changes, the left ventricular diastolic function can be easily assessed by Doppler measurement of the mitral inflow. However, there are many physiologic and hemodynamic factors responsible for the mitral inflow. This study was designed to evaluate several parameters that represent the left ventricular function during the transitional circulation period.

Subjects and Methods

Eighteen normal full-term infants were studied by serial two-dimensional, Doppler and color flow echocardiography within 24 hours before and after birth, between 2 days and 6 days after birth and between 7 days and 30 days after birth).

Results

One day after birth, the mitral valve (MV) E velocity and E/A increased (37.9±7.5 vs. 60.3±9.0 and 0.8±0.1 vs. 1.1±0.1, p<0.01, respectively), but the MV A velocity, the velocity of propagation (Vp), the LV isovolumic relaxation time (IVRT), the corrected IVRT and the tissue Doppler ventricular septum e' and s' did not change. Although Vp/E and a' decreased (1.2±0.3 vs. 0.7±0.2 and 8.2±1.8 vs. 6.5±1.7, p<0.05, respectively), the E/e' and the systolic and diastolic pulmonary venous flow velocities increased after birth (6.3±1.9 vs. 11.6±2.9, and 26.1±6.7 vs. 64.5±9.6, and 20.9±4.1 vs. 63.5±17.2, p<0.05, respectively).

Conclusion

Increased preload plays a key role for the increased MV E/A ratio after birth. Other unknown factors (and possibly including pericardial restriction) may be also responsible for left ventricular diastolic function.

Keywords: Diastolic function

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