Journal List > Korean Circ J > v.35(12) > 1016069

TOOLS
Kim, Yoon, Jung, Wang, Choi, Jung, Kim, Yoo, Lee, Uh, Hwang, and Choe: A Diagnostic Value of Ischemia Modified Albumin in Patients with Suspected Acute Coronary Syndrome with Normal EKG and Cardiac Markers
Original Article
Korean Circulation Journal

Korean Circulation Journal 2005; 35(12): 928-933.

Published online: 31 December 2005

DOI: https://doi.org/10.4070/kcj.2005.35.12.928

A Diagnostic Value of Ischemia Modified Albumin in Patients with Suspected Acute Coronary Syndrome with Normal EKG and Cardiac Markers

Jang Young Kim, Junghan Yoon, Il Hyung Jung, Hee Sung Wang, Hoon Choi, Hyun Sook Jung, Hyun Kim, Byung Soo Yoo, Seung Hwan Lee, Young Uh, Sung Oh Hwang, Kyung Hoon Choe

Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, Korea.

Department of Emergency Medicine, Yonsei University, Wonju College of Medicine, Wonju, Korea.

Department of Clinical Pathology, Yonsei University, Wonju College of Medicine, Wonju, Korea.

yoonj@wonju.yonsei.ac.kr

Copyright © 2005 The Korean Society of Circulation

Abstract

BACKGROUND AND OBJECTIVES: In the early phase of acute chest pain, the diagnosis of acute coronary syndrome (ACS) is often difficult to achieve in an emergency department (ED) due to the non-diagnostic ECG and cardiac markers. Ischemia modified albumin (IMA) has recently been shown to be a sensitive early biochemical marker of ischemia. The aim of this study was to evaluate the diagnostic value of IMA for the patients with suspected ACS and who have normal ECG/cardiac markers.
SUBJECTS AND METHODS: We enrolled 142 consecutive patients who presented to the ED due to suspected ACS, and they had a normal EKG and troponin-I/CK-MB within 5 hours after the onset of their chest pain. The diagnosis of ACS was based upon the clinical findings, the results of serial ECG/troponin and the coronary angiography. The ideal cutoff value of IMA for ACS was calculated by the receiver operator characteristic (ROC) curve analysis.
RESULTS: The ACS was diagnosed in 80/142 (56%). The ROC curve area for the IMA test was 0.77 (CI; 0.70-0.85, p<0.01). At a cutoff value of 98.5 U/mL, the sensitivity, specificity and negative predictive values for ACS were 73%, 75% and 75%, respectively. At a cutoff value of 85 U/mL, the sensitivity and specificity and negative predictive values for ACS were 92%, 35% and 95%, respectively.
CONCLUSION: IMA might be a useful diagnostic marker of ACS for those patients with normal ECG/cardiac markers and who present within 5 hours after the onset of chest pain.

Keywords: Coronary disease, Ischemia, Myocardium

TOOLS
Similar articles