Journal List > Korean Circ J > v.35(2) > 1015950

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Kim, Chang, Koh, Seung, Baek, Shin, Lim, Kim, Hong, and Choi: Functional Polymorphism in the Promoter Region of Matrix Metalloproteinase-9 is Strongly Associated with Acute Myocardial Infarction
Case Report
Korean Circulation Journal

Korean Circulation Journal 2005; 35(2): 192-196.

Published online: 28 February 2005

DOI: https://doi.org/10.4070/kcj.2005.35.2.192

Functional Polymorphism in the Promoter Region of Matrix Metalloproteinase-9 is Strongly Associated with Acute Myocardial Infarction

Pum Joon Kim, Kiyuk Chang, Yoon Seok Koh, Ki Bae Seung, Sang Hong Baek, Woo Seung Shin, Sang Hyun Lim, Jae Hyung Kim, Soon Jo Hong, Kyu Bo Choi

Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Uijeongbu St. Mary's Hospital, Uijieongbu, Korea.

kiyuk@catholic.ac.kr

Copyright © 2005 The Korean Society of Circulation

Abstract

BACKGROUND AND OBJECTIVES: Matrix metalloproteinase-9 (MMP-9) plays an important role in the genesis of atherosclerotic plaque rupture and acute coronary syndrome (ACS), including an acute myocardial infarction (AMI). A single nucleotide polymorphism (SNP) in the MMP-9 promoter (-1562C>T) has recently been identified. This study investigated whether the SNP of the MMP-9 promoter is a significant risk factor for an AMI due to plaque rupture and if SNPs affect the transcription of the gene that elevates the MMP-9 expression level.
SUBJECTS AND METHODS: A polymerase chain reaction, followed by a restriction fragment length polymorphism analysis, was performed in 173 control participants and 206 AMI patients. The serum levels of MMP-9 in the groups with or without the SNP were measured, using ELISA, and compared.
RESULTS: There was a significantly higher incidence of the -1562C>T MMP-9 polymorphism in the AMI compared to the control group (27.6% vs. 17.9%, p=0.04). A multiple logistic regression analysis of the risk factors for coronary artery disease and the MMP-9 polymorphism showed the MMP-9 polymorphism to be an important factor in the prediction of an AMI (odds ratio 1.67, 95% confidence interval 1.02-2.67, p=0.04).
CONCLUSION: The -1562C>T polymorphism in the MMP-9 promoter is a definite risk factor for an AMI, and is associated with elevated MMP-9 expression. These results suggest that a SNP in the MMP-9 promoter is strongly associated with an Acute Myocardial Infarction.

Keywords: Matrix metalloproteinase-9, Polymorphism, Acute myocardial infarction

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