Journal List > Korean J Perinatol > v.27(2) > 1013792

Korean J Perinatol. 2016 Jun;27(2):122-126. Korean.
Published online June 30, 2016.
Copyright © 2016 The Korean Society of Perinatology
A Case of Rotavirus Infection Presenting with Direct Hyperbilirubinemia
Jong Seok Ha, M.D., Seon Hwa Lee, M.D., Tae Yeon Yoo, M.D., Hye Won Park, M.D. and Min Hee Kim, M.D., Ph.D.
Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

Correspondence to: Min Hee Kim, M.D. Department of Pediatrics, Division of Neonatology, Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-Ro, Hwayang-dong, Gwangjin-gu, Seoul 05030, Korea. Tel: +82-2-2030-5120, Fax: +82-2-2030-5122, Email:
Received March 24, 2016; Revised June 11, 2016; Accepted June 12, 2016.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Rotavirus is the most common cause of infectious gastroenteritis in infants and young children and estimated to cause more than 111 million cases of diarrhea annually. Most patients show no specific symptom or experience mild fever, vomiting, non-bloody diarrhea and symptoms often resolve within several days. However, some of patients suffer from severe complication such as necrotizing enterocolitis, intussusception, seizure, encephalitis, and cholestasis. We report a neonatal case of rotavirus infection presenting with reversible direct hyperbilirubinemia with a brief review of associated literatures.

Keywords: Rotavirus infection; Newborn; Direct hyperbilirubinemia


Fig. 1
The trend of total bilirubin and direct bilirubin during hospitalization and follow-up after discharge from hospital. Abbreviations: HD, hospital day; DD, day after discharge.
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Fig. 2
The findings of hepatobiliary scan on the 8th hospital days. 99mTc-3-bromo-2,4,6-trimethyl-IDA hepatobiliary scintigraphy of patient shows no passage disturbance of radiotracer in biliary tree and no evidence of biliary atresia.
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