A Case of Rotavirus Infection Presenting with Direct Hyperbilirubinemia

doi:10.14734/kjp.2016.27.2.122

Journal List > Korean J Perinatol > v.27(2) > 1013792


Korean J Perinatol. 2016 Jun;27(2):122-126. Korean. Published online June 30, 2016. https://doi.org/10.14734/kjp.2016.27.2.122
Copyright © 2016 The Korean Society of Perinatology


A Case of Rotavirus Infection Presenting with Direct Hyperbilirubinemia
Jong Seok Ha, M.D., Seon Hwa Lee, M.D., Tae Yeon Yoo, M.D., Hye Won Park, M.D. and Min Hee Kim, M.D., Ph.D.
Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
Correspondence to: Min Hee Kim, M.D. Department of Pediatrics, Division of Neonatology, Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-Ro, Hwayang-dong, Gwangjin-gu, Seoul 05030, Korea. Tel: +82-2-2030-5120, Fax: +82-2-2030-5122, Email: kmh@kuh.ac.kr

Received March 24, 2016; Revised June 11, 2016; Accepted June 12, 2016.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract
Rotavirus is the most common cause of infectious gastroenteritis in infants and young children and estimated to cause more than 111 million cases of diarrhea annually. Most patients show no specific symptom or experience mild fever, vomiting, non-bloody diarrhea and symptoms often resolve within several days. However, some of patients suffer from severe complication such as necrotizing enterocolitis, intussusception, seizure, encephalitis, and cholestasis. We report a neonatal case of rotavirus infection presenting with reversible direct hyperbilirubinemia with a brief review of associated literatures.


Keywords: Rotavirus infection; Newborn; Direct hyperbilirubinemia

Figures


	Fig. 1 The trend of total bilirubin and direct bilirubin during hospitalization and follow-up after discharge from hospital. Abbreviations: HD, hospital day; DD, day after discharge.
	Click for larger imageDownload as PowerPoint slide


	Fig. 2 The findings of hepatobiliary scan on the 8^th hospital days. 99mTc-3-bromo-2,4,6-trimethyl-IDA hepatobiliary scintigraphy of patient shows no passage disturbance of radiotracer in biliary tree and no evidence of biliary atresia.
	Click for larger imageDownload as PowerPoint slide

References


1.	Anderson EJ, Weber SG. Rotavirus infection in adults. Lancet Infect Dis 2004;4:91–99.

2.	Kapikian AZ. Viral gastroenteritis. JAMA 1993;269:627–630.

3.	Moon HH, Kim DS, Park SH, Kim H. Clinical characteristics and genotype of rotavirus infection in newborn infants. Korean J Perinatol 2012;23:266–272.

4.	Sugata K, Taniguchi K, Yui A, Miyake F, Suga S, Asano Y, et al. Analysis of rotavirus antigenemia and extraintestinal manifestations in children with rotavirus gastroenteritis. Pediatrics 2008;122:392–397.

5.	Kim DK, Jeong DS, Kim CR, Oh SH, Moon SJ. Clinical and epidemiologic features of rotavirus outbreak in a nursery. J Korean Soc Neonatol 2003;10:208–217.

6.	Rodriguez WJ, Kim HW, Brandt CD, Schwartz RH, Gardner MK, Jeffries B, et al. Longitudinal study of rotavirus infection and gastroenteritis in families served by a pediatric medical practice: clinical and epidemiologic observations. Pediatr Infect Dis J 1987;6:170–176.

7.	de Villiers FP, Steele AD, Driessen M. Central nervous system involvement in neonatal rotavirus infection. Ann Trop Paediatr 2003;23:309–312.

8.	Saulsbury FT, Winkelstein JA, Yolken RH. Chronic rotavirus infection in immunodeficiency. J Pediatr 1980;97:61–65.

9.	Sızmaz E, Satar M, Ozlü F, Yaman A, Yıldızdaş HY, Ozcan K. The coincidence of necrotizing enterocolitis and rotavirus infections and potential associations with cytokines. Can J Infect Dis Med Microbiol 2012;23:e103–e105.

*10.*	Konno T, Suzuki H, Kutsuzawa T, Imai A, Katsushima N, Sakamoto M, et al. Human rotavirus and intussusception. N Engl J Med 1977;297:945.

*11.*	Takahashi S, Oki J, Miyamoto A, Koyano S, Ito K, Azuma H, et al. Encephalopathy associated with haemophagocytic lymphohistiocytosis following rotavirus infection. Eur J Pediatr 1999;158:133–137.

*12.*	Riepenhoff-Talty M, Gouvea V, Evans MJ, Svensson L, Hoffenberg E, Sokol RJ, et al. Detection of group C rotavirus in infants with extrahepatic biliary atresia. J Infect Dis 1996;174:8–15.

*13.*	Sanghai SR, Shah I, Bhatnagar S, Murthy A. Incidence and prognostic factors associated with biliary atresia in western India. Ann Hepatol 2009;8:120–122.

*14.*	Ko JS, Seo JK. The etiologies of neonatal cholestasis. Korean J Pediatr 2007;50:835–840.

*15.*	Naini BV, Lassman CR. Total parenteral nutrition therapy and liver injury: a histopathologic study with clinical correlation. Hum Pathol 2012;43:826–833.

*16.*	Hertel PM, Estes MK. Rotavirus and biliary atresia: can causation be proven? Curr Opin Gastroenterol 2012;28:10–17.

*17.*	Shivakumar P, Sabla GE, Whitington P, Chougnet CA, Bezerra JA. Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia. J Clin Invest 2009;119:2281–2290.

*18.*	St-Jules DE, Watters CA, Iwamoto LM. Use of fish oil-based lipid emulsions in infants with intestinal failure-associated liver disease: a case series. Infant Child Adolesc Nutr 2014;6:6–13.

*19.*	Park HW, Lee NM, Kim JH, Kim KS, Kim SN. Parenteral fish oil-containing lipid emulsions may reverse parenteral nutrition-associated cholestasis in neonates: a systematic review and meta-analysis. J Nutr 2015;145:277–283.

*20.*	Shneider BL, Magee JC, Bezerra JA, Haber B, Karpen SJ, Raghunathan T, et al. Efficacy of fat-soluble vitamin supplementation in infants with biliary atresia. Pediatrics 2012;130:e607–e614.