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Abstract
Materials and Methods
A total of 101 children aged 2 to 15 years with spinal tuberculosis, accompanied by various stages of disease processes were enrolled for analysis. By utilizing the images in them, the growth plate condition and chronological changes of kyphosis after chemotherapy were analyzed at two points in time; the first assessment was at post-chemotherapy one-year and second at the final discharge.
Results
Complete disc destruction in the cervical, dorsal and lumbosacral spines was observed in 2 out of 40 children (5.0%), 8 out of 30 children (26.7%), and 6 out of 31 children (19.4%), respectively. In those cases, the residual kyphosis inevitably developed. In the remaining children, the discs were intact or partially damaged. Among the 101 children kyphotic deformity was maintained without change in 20 children (19.8%). Kyphosis decreased in 14 children (13.9%), while it increased in 67 children (66.3%) with non-recoverably damaged growth plate.
Conclusion
Although it is tentatively possible to predict the deformity progress or non-progress and spontaneous correction at the time of the initial treatment, its predictive accuracy is low. Therefore, assessment of the chronological changes should be performed at the end of chemotherapy. In children with progressive curve change, assessment of deformity should be continued until maturity.
Figures and Tables
Figure 1
Tuberculosis of C3–6 in a 5-year-old boy. (A) Initial lateral radiograph showing narrowed disc spaces of C3–4, C4–5, and C5–6 with round cervical kyphosis and huge prevertebral soft tissue shadow. Initially, cervical traction was applied in bed for 3 weeks under the cover of triple chemotherapy which was followed by a Minerva cast for 5 weeks. Radiograms taken at postchemotherapy, 18 months (B), and 36 months (C) are shown in which gradual spontaneous correction of kyphosis and visible undestroyed affected the discs and reformation of the diseased vertebral bodies. Radiograms, taken at 4 and 20 years (D, E) after initial chemotherapy, showed the fused C2–6 block vertebra circumferentially with good spontaneous correction of kyphosis.
Figure 2
Tuberculosis of cervical spine at C5–7 in a 2-year-old paraplegic boy, treated by triple antituberculous chemotherapy (isoniazid, rifampin, ethambutol) for 12 months. Serial lateral radiograms, taken at the initial radiogram (A), 12 months (B), 24 months (C), and 36 months (D) are shown. (A) The initial radiogram shows the almost completely destroyed C6 body with minimum kyphosis. (B) After chemotherapy there were no further vertebral body destruction, while slippage of C5 over C7 occurred due to facet joint gapping at 12 months. (C, D) However anterior C5 slippage was well reduced and stabilized spontaneously at 24 and 36 months.
Figure 3
Tuberculosis of the thoracic spine at D9–11 in a 5-year-old boy; arrows indicate the lesion. (A, A1) The initial radiogram show the flattened D10 vertebral body with mild kyphosis (Cobb angle 18°), and the disease arrest. Gradual correction of kyphosis (Cobb angle 10°) is seen at 12 months (B, B1) and 18 months (C, C1) after triple chemotherapy. Intercorporal fusion did not occur.
Figure 4
Serial follow-up radiograms of L1–2 tuberculosis show unfused thin bloc L1 body and wedged. L2 body which formed the kyphosis. (A) Initial; (B) 6 months; (C) 12 months; (D) 18 months; (E) 36 months.
Figure 5
Tuberculosis of L2–3 in a 6-year-old boy, treated conservatively with triple chemotherapy (isoniazid, rifampin, ethambutol) for 12 months (A, A1). The disease was well healed with relatively well-preserved L2–3 disc as well as affected L2 and L3 bodies (B-D, B1-D1).
Figure 6
Tuberculosis of L3–4 in a 7-year-old boy, treated conservatively with triple chemotherapy for 12 months. The initial radiograms showed incompletely fused L3–4 bodies with cystic lesion in anteroinferior part of L3 body (A, A1) which was maintained until the final follow-up (B-D, B1-D1). The flattened lumbar curve is observed.
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