Synovial Sarcoma of the Extremities

Jang Yong Moon; So Hak Chung; Sun Ju Oh

doi:10.4055/jkoa.2016.51.6.503

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Moon, Chung, and Oh: Synovial Sarcoma of the Extremities

Original Article

Journal of the Korean Orthopaedic Association 2016; 51(6): 503-508.

Published online: 30 December 2016

DOI: https://doi.org/10.4055/jkoa.2016.51.6.503

Synovial Sarcoma of the Extremities

Jang Yong Moon, M.D., So Hak Chung, Ph.D., Sun Ju Oh, M.D.

Department of Orthopaedic Surgery, Kosin University Gospel Hospital, Busan, Korea.

Correspondence to: So Hak Chung, Ph.D. Department of Orthopaedic Surgery, Kosin University Gospel Hospital, 262 Gamcheon-ro, Seo-gu, Busan 49267, Korea. TEL: +82-51-990-6467, FAX: +82-51-243-0181, shchung@kosin.ac.kr

Received 27 December 2015 Revised 13 April 2016 Accepted 26 June 2016

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

Synovial sarcoma is an uncommon malignant soft tissue tumor mostly prevalent in young adults. Previous studies analyzing the prognostic factors have been limited due to the inclusion of heterogenous cohorts of patients with nonextremity and recurrent tumors. The purpose of this study was to determine the independent prognostic factors for the treatment methods associated with local recurrence and metastasis of primary synovial sarcoma localized to the extremities.

Materials and Methods

Between April 1999 and June 2014, a total of 79 patients were diagnosed with synovial sarcoma, of which 73 underwent wide excision at Kosin University Gospel Hospital and were followed-up for 60 months (24-72 months). The analyzed prognostic factors were treatment methods for local recurrence and metastasis during the postoperative follow-up period. The Cox regression model was used for multivariate analysis.

Results

For local recurrence according to the treatment methods, 9 recurrences occurred in 9 surgical treatments, 8 in 20 chemotherapy added surgical treatments, 13 in 20 radiotherapy added surgical treatments, and 4 in 24 chemotherapy with radiotherapy added surgical treatments. For metastasis according to the treatment methods, 9, 5, 12, and 2 metastases occurred respectively. Chemotherapy had statistical significance in multivariate analysis (p<0.0001).

Conclusion

Adjuvant chemotherapy can be useful for the treatment of synovial sarcoma.

Keywords: synovial sarcoma, therapy, survival rate, local neoplasm recurrence, neoplasm metastasis

Figures and Tables

Figure 1

This graph shows the continuous disease free survival proportions of the chemotherapy and non-chemotherapy groups. By the log-rank test, the p-value was less than 0.0001.

Figure 2

This graph shows the continuous disease free survival proportions of the radiotherapy and non-radiotherapy groups. By the logrank test, the p-value was 0.07.

Figure 3

This graph shows the continuous disease free survival proportions of the local recurrence and no local recurrence groups. By the logrank test, the p-value was less than 0.0001.

Figure 4

This graph shows the continuous disease free survival proportions of the metastasis and non-metastasis groups. By the logrank test, the p-value was less than 0.0001.

Table 1

Distribution of Clinical, Pathological, and Treatment Characteristics in 73 Patients

Values are presented as number (%).

Table 2

Test for Model Coefficient

Table 3

Multivariate Analysis (Cox Regression Model)

^*Exp(B) represent odds ratio or relative risk. CI, confidence interval.

Notes

^{CONFLICTS OF INTEREST} The authors have nothing to disclose.

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