Journal List > J Korean Orthop Assoc > v.51(6) > 1013484

Kim, Lee, Kim, Lim, Choi, Kim, Kim, and Lee: Risk Factors for Subsequent Vertebral Compression Fracture Following Osteoporotic Compression Fracture



To evaluate the risk factors for subsequent vertebral fracture following acute osteoporotic vertebral compression fracture.

Materials and Methods

This was a multicenter retrospective study. We recruited 135 patients treated for acute osteoporotic compression fracture with available spine image taken at the 1-year follow-up mark in 3 different hospitals. The patients were divided into 2 groups in accordance with the occurrence of subsequent vertebral fracture. Variables including age, sex, bone mineral density, medical comorbidity, acute fracture level, presence of prior vertebral fracture, osteoporosis medication, and treatment method were analyzed and compared between the 2 groups.


The new subsequent vertebral fractures were detected in 25 patients (18.5%). There were no significant differences between the 2 groups with respect to age, sex, medical comorbidity, presence of prior vertebral fracture, and acute fracture level, as shown by univariate analysis. However, in the group with subsequent vertebral fracture, more patients were treated by vertebroplasty or kyphoplasty and had a femur neck T-score of ≤-2.5, as well as poor compliance of osteoporosis medication with significant difference (p<0.05). According to the multivariate analysis, subsequent vertebral fractures were significantly influenced by vertebroplasty or kyphoplasty (p=0.003, odds ratio=4.71) and femur neck T-score of ≤-2.5 (p=0.013, odds ratio=3.47).


Subsequent vertebral fractures were found in 19% at the 1-year mark after the treatment of acute osteoporotic compression fracture. The two risk factors for subsequent vertebral fractures were vertebroplasty or kyphoplasty and femur neck T-score of ≤-2.5.

Figures and Tables

Table 1

Demographics and BMD


Values are presented as mean±standard deviation (range), number only or mean±standard deviation only. BMD, bone mineral density.

Table 2

Univariate Analysis for Subsequent Vertebral Compression Fracture


N, no; Y, yes; CI, confidence interval; BMD, bone mineral density; MRP, medication possession rate.

Table 3

Multivariate Analysis for Subsequent Vertebral Compression Fracture


*Vertebroplasty or kyphoplasty vs. conservative. T≤−2.5 vs. T>−2.5. Poor vs. good. CI, confidence interval; BMD, bone mineral density.


CONFLICTS OF INTEREST The authors have nothing to disclose.


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