Neurolymphomatosis Involving Antebrachial Cutaneous Nerve

Yu-Hun Jung; Woo-Suk Song; Sub-Ri Park; So-Ya Paik

doi:10.4055/jkoa.2016.51.4.345

Journal List > J Korean Orthop Assoc > v.51(4) > 1013464

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Jung, Song, Park, and Paik: Neurolymphomatosis Involving Antebrachial Cutaneous Nerve

Case Report

Journal of the Korean Orthopaedic Association 2016; 51(4): 345-349.

Published online: 11 August 2016

DOI: https://doi.org/10.4055/jkoa.2016.51.4.345

Neurolymphomatosis Involving Antebrachial Cutaneous Nerve

Yu-Hun Jung, M.D., Woo-Suk Song, M.D., Sub-Ri Park, M.D., So-Ya Paik, M.D.^*

Department of Orthopedic Surgery, Bundang Jesaeng General Hospital, Seongnam, Korea.

^*Department of Pathology, Bundang Jesaeng General Hospital, Seongnam, Korea.

Correspondence to: Woo-Suk Song, M.D. Department of Orthopedic Surgery, Bundang Jesaeng General Hospital, 20 Seohyeon-ro 180beon-gil, Bundang-gu, Seongnam 13590, Korea. TEL: +82-31-779-0175, FAX: +82-31-779-0179, ncd1896@naver.com

Received 5 October 2015 Revised 23 November 2015 Accepted 30 December 2015

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The term neurolymphomatosis has included infiltration of the peripheral nervous system by lymphoma. In generally, direct invasion of the peripheral nervous system is rare. The difficulty in treatment of neurolymphomatosis is due to unclassified characteristic symptoms and diagnosis. We performed excision of mass on the antebrachial cutaneous nerve with no specific symptoms. After diagnosis of diffuse large B cell lymphoma, further treatment and observation were followed. However, recurrence of the lymphoma was found in the ipsilateral forearm ulnar nerve, therefore we described a case of neurolymphomatosis with a brief review of the literature.

Keywords: neurolymphomatosis, diffuse large B cell lymphoma, antebrachial cutaneous nerve, ulnar nerve

Figures and Tables

Figure 1

Intermediate/heterogeneous high signal in T2 weighted (A), contrast enhanced (B), T1 weighted (C) magnetic resonance imaging of the right foream volar side shows that a well marginated ovoid mass passes through the anterior or lateral antebracial cutaneous nerve.

Figure 2

Diffuse infiltration of large to medium sized neoplastic lymphoid cells. Note lymphoma cells invading a large nerve bundle (H&E, ×200).

Figure 3

Immunohistochemical stains showed the tumor cells to be diffusely positive to CD20 (A) and Bcl-2 (B) (A, B: ×200).

Figure 4

T2 weighted (A) and contrast enhanced (B) magnetic resonance imaging of the right medial elbow side shows that the lobulated enhancing mass passes through the ulnar nerve course.

Notes

^{CONFLICTS OF INTEREST} The authors have nothing to disclose.

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