Current Strategy of Chemotherapy for Bone Tumors

Hyo Song Kim; Sun Young Rha

doi:10.4055/jkoa.2015.50.6.438

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Kim and Rha: Current Strategy of Chemotherapy for Bone Tumors

Symposium

Diagnosis and Treatment of Malignant Bone Tumors

Journal of the Korean Orthopaedic Association 2015; 50(6): 438-443.

Published online: 29 December 2015

DOI: https://doi.org/10.4055/jkoa.2015.50.6.438

Current Strategy of Chemotherapy for Bone Tumors

Hyo Song Kim, M.D., Ph.D., Sun Young Rha, M.D., Ph.D.

Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Correspondence to: Sun Young Rha, M.D., Ph.D. Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonseo-ro, Seodaemun-gu, Seoul 03722, Korea. TEL: +82-2-2228-8050, FAX: +82-2-393-3652, rha7655@yuhs.ac

Received 23 October 2015 Accepted 7 November 2015

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Despite the rarity of primary bone tumors, osteosarcoma and Ewing sarcoma are the most common primary malignant bone tumors in children and adolescents. Multiagent chemotherapy regimens for neoadjuvant and adjuvant treatment remarkably improved the survival outcome for patients with osteosarcoma and Ewing sarcoma, therefore, most patients are now limb-salvage candidates. However, survival rate reached a plateau for last decades and is still unsatisfactory in the metastatic and relapse setting. Therefore, as seen in denosumab in giant cell tumor, further clinical trials based on molecular mechanism are warranted. This article reviews the current state of the art of systemic chemotherapy by focusing on the clinical heterogeneity of each subtype.

Keywords: bone tumor, chemotherapy

Figures and Tables

Table 1

Perioperative Chemotherapy Regimens of Osteosarcoma in Clinical Trials

EOI, European Osteosarcoma Intergroup; SSG, Scandinavian Sarcoma Group; EURAMOS, European and American Osteosarcoma Study Group; A, adriamycin; P, cisplatin; MAP, methotrexate, doxorubicin, cisplatin; G-CSF, granulocyte colony-stimulating factor; preop, preoperative; GR, good responder; PR, poor responder; IE, ifosfamide, etoposide; I, ifosfamide; M, methotrexate; MA, methotrexate, doxorubicin; IFN, interferon; E, etoposide; EFS, event-free survival; OS, overall survival; HR, hazard ratio; AP, doxorubicin, cisplatin; PFS, progression-free survival.

Notes

^{CONFLICTS OF INTEREST} The authors have nothing to disclose.

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