Development of Conventional Osteosarcoma after 13 Years Continuous Disease-free Survival of Periosteal Osteosarcoma

Chang-Bae Kong; Yunsuk Hong; Jae-Soo Koh; Dae-Geun Jeon

doi:10.4055/jkoa.2011.46.2.158

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Kong, Hong, Koh, and Jeon: Development of Conventional Osteosarcoma after 13 Years Continuous Disease-free Survival of Periosteal Osteosarcoma

Case Report

Journal of the Korean Orthopaedic Association

Journal of the Korean Orthopaedic Association 2011; 46(2): 158-161.

Published online: 22 April 2011

DOI: https://doi.org/10.4055/jkoa.2011.46.2.158

Development of Conventional Osteosarcoma after 13 Years Continuous Disease-free Survival of Periosteal Osteosarcoma

Chang-Bae Kong, M.D., Yunsuk Hong, M.D., Jae-Soo Koh, M.D.^*, Dae-Geun Jeon, M.D.

Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea.

^*Department of Pathology, Korea Cancer Center Hospital, Seoul, Korea.

Correspondence to: Dae-Geun Jeon, M.D. Department of Orthopedic Surgery, Korea Cancer Center Hospital, 215-4, Gongneung-dong, Nowon-gu, Seoul 139-706, Korea. TEL: +82-2-970-1242, FAX: +82-2-970-2403, dgjeon@kcch.re.kr

Received 1 June 2010 Accepted 4 December 2010

(open-access):

"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited."

Abstract

Periosteal osteosarcoma is a rare variant of osteosarcoma and has represented 1-2% of all osteosarcomas. Most local recurrences or progression to metastatic disease occurred within the first 3 years after presentation and lung metastasis is more common than bony metastasis. We describe a periosteal osteosarcoma of tibia patient who developed conventional osteosarcoma of proximal humerus after 13 years from the completion of treatment.

Keywords: primary malignant bone tumor, periosteal osteosarcoma, conventional osteosarcoma

Figures and Tables

Figure 1

(A) Plain anteroposterior and lateral radiographs of right tibia of a 10-year-old boy show bony lesion arising from surface of bone. Marrow does not appear to be involved. (B) MR images demonstrate lesion arising from surface of bone. Marrow does not appear to be involoved. (C) Photomicrograph shows that lobules of malignant cartilage are separated by malignant spindle cells producing osteoid. (D) Radiographs show the reconstructed tibia using bone cement with multiple ender nails.

Figure 2

(A) Anteroposterior radiograph of left humerus shows osteosclerotic lesion involving epiphysis of head and proximal meta-diaphysis. Note periosteal reaction of medial aspect of proximal humerus. (B) The left shoulder T2-weighted MR coronal image demonstrates tumor within bone and soft tissue. (C) Enhanced T1-weighted MR coronal image shows heterogeneous enhancement. (D) Photomicrograph reveals the conventional osteoblastic osteosarcoma.

References

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