Aberrant Chromosomal Alterations in Bizarre Parosteal Osteochondromatous Proliferation (Nora's Lesion) of Hand - A Case Report -

Kap-Jung Kim; Ha Yong Kim; Dae Suk Yang; Won-Sik Choy; Chun Wha Ihm

doi:10.4055/jkoa.2008.43.2.247

Journal List > J Korean Orthop Assoc > v.43(2) > 1012774

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Kim, Kim, Yang, Choy, and Ihm: Aberrant Chromosomal Alterations in Bizarre Parosteal Osteochondromatous Proliferation (Nora's Lesion) of Hand - A Case Report -

Case Report

Journal of the Korean Orthopaedic Association

Journal of the Korean Orthopaedic Association 2008; 43(2): 247-251.

Published online: 30 April 2008

DOI: https://doi.org/10.4055/jkoa.2008.43.2.247

Aberrant Chromosomal Alterations in Bizarre Parosteal Osteochondromatous Proliferation (Nora's Lesion) of Hand - A Case Report -

Kap-Jung Kim, M.D., Ha Yong Kim, M.D., Dae Suk Yang, M.D., Won-Sik Choy, M.D., Chun Wha Ihm, M.D.^*

Department of Orthopaedic Surgery, Eulji University College of Medicine, Daejeon, Korea.

^*Department of Laboratory Medicine, Eulji University College of Medicine, Daejeon, Korea.

Address reprint requests to Kap-Jung Kim, M.D. Department of Orthopaedic Surgery, Eulji University College of Medicine, 1306, Dunsan-dong, Seo-gu, Daejeon 302-102, Korea. Tel: +82.42-611-3279, Fax: +82.42-259-1289, oskkj@eulji.ac.kr

Abstract

Bizarre parosteal osteochondromatous proliferation is a disease similar to an osteochondroma that usually involves the metatarsal, metacarpal, proximal and middle phalanx. The symptoms are normally caused by the bone mass, the condition has a benign clinical course but recurrence is common. Recently, it was reported that there is a translocation between chromosome 1 and 17. We report a case of BPOP in the middle phalanx of hand with translocations and duplication in cytogenetic karyotyping with a review of relevant literature.

Keywords: Hand, Bizarre parosteal osteochondromatous proliferation, Cytogenetic karyotyping

Figures and Tables

Fig. 1

Photographs showing a dorsoulnar bony mass located in the middle phalanx of the 4^th finger.

Fig. 2

Preoperative radiographs showing a 7×7 mm sized exostotic mass on the dorsoulnar aspect middle phalanx of the 4^th finger. The protruding bony mass does not connect with the medullary cavity of middle phalanx.

Fig. 3

Computed tomography scans showing an irregular and calcified mass of the middle phalanx.

Fig. 4

Intraoperative photograph showing a whitish and irregular calcified mass.

Fig. 5

Photomicrograph showing a bizarre chondrocyte, osteoid and spindle cells that favor bizarre parosteal osteochondromatous proliferation (BPOP).

Fig. 6

Cytogenetic karyotyping showing t(3;17)(p21;p13), t(7;15)(q32;q15) and dup(15)(q15;q22).

Fig. 7

Postoperative 12 months radiographs showing no evidence of local recurrence.

References

1. Breidahl WH, Wylie EJ. Bizarre parosteal osteochondromatous proliferation of the hands and feet. Australas Radiol. 1995. 39:401–404.

2. Choi JH, Gu MJ, Kim MJ, Choi WH, Shin DS, Cho KH. Fibrosarcoma in bizarre parosteal osteochondromatous proliferation. Skeletal Radiol. 2001. 30:44–47.

3. Endo M, Hasegawa T, Tashiro T, et al. Bizarre parosteal osteochondromatous proliferation with a t(1;17) translocation. Virchows Arch. 2005. 447:99–102.

4. Kim BH, Park YK, Kim YW, Yang MH. Bizarre parosteal osteochondromatous proliferation: A report of five cases. Korean J Pathol. 1996. 30:733–738.

5. Meneses MF, Unni KK, Swee RG. Bizarre parosteal osteochondromatous proliferation of bone (Nora's lesion). Am J Surg Pathol. 1993. 17:691–697.

6. Nilsson M, Domanski HA, Mertens F, Mandahl N. Molecular cytogenetic characterization of recurrent translocation breakpoints in bizarre parosteal osteochondromatous proliferation (Nora's lesion). Hum Pathol. 2004. 35:1063–1069.

7. Nora FE, Dahlin DC, Beabout JW. Bizarre parosteal osteochondromatous proliferation of hands and feet. Am J Surg Pathol. 1983. 7:245–250.

8. Spjut HJ, Dorfman HD. Florid reactive periositis of the tubular bones of the hands and feet. A benign lesion which may simulate osteosarcoma. Am J Surg Pathol. 1981. 5:423–433.

9. Twiston Davies CW. Bizarre parosteal osteochondromatous proliferation in the hand. A case report. J Bone Joint Surg Am. 1985. 67:648–650.

10. van der Walt JD, Ryan JF. Parosteal osteogenic sarcoma of the hand. Histopathology. 1990. 16:75–78.

TOOLS

Similar articles